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Anti-CD3 epsilon/CD3e Antibody (2D709)

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Anti-CD3 epsilon/CD3e Antibody (2D709)
产品编号 TMAY-01397
别名 CD3e molecule, ε (CD3-TCR complex), CD3e molecule, epsilon (CD3-TCR complex), CD3 ε/CD3e

Anti-CD3 epsilon/CD3e Antibody (2D709) 是一种 Mouse 抗体，靶向 CD3 epsilon/CD3e。Anti-CD3 epsilon/CD3e Antibody (2D709) 可用于 WB。

Anti-CD3 epsilon/CD3e Antibody (2D709)
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Anti-CD3 epsilon/CD3e Antibody (2D709)

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Anti-CD3 epsilon/CD3e Antibody (2D709)
产品编号 TMAY-01397 别名 CD3e molecule, ε (CD3-TCR complex), CD3e molecule, epsilon (CD3-TCR complex), CD3 ε/CD3e

Anti-CD3 epsilon/CD3e Antibody (2D709) 是一种 Mouse 抗体，靶向 CD3 epsilon/CD3e。Anti-CD3 epsilon/CD3e Antibody (2D709) 可用于 WB。

规格价格库存数量
100 μL
¥ 1,679
5日内发货
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产品介绍

生物活性
产品描述
Anti-CD3 epsilon/CD3e Antibody (2D709) is a Mouse antibody targeting CD3 epsilon/CD3e. Anti-CD3 epsilon/CD3e Antibody (2D709) can be used in WB.
别名CD3e molecule, ε (CD3-TCR complex), CD3e molecule, epsilon (CD3-TCR complex), CD3 ε/CD3e
Ig Type
Mouse IgG1
克隆号
2D709
交叉反应
Human
验证活性
Anti-CD3E mouse monoclonal antibody at 1:500 dilution.
-Lane A: Jurkat Whole Cell lysate.
-Lysates/proteins at 30 μg per lane.
-Secondary
-Goat Anti-Mouse IgG (H+L)/HRP at 1/10000 dilution.
-Developed using the ECL technique.
-Performed under reducing conditions.
-Predicted band size:23 kDa.
-Observed band size:23 kDa
应用
WB
推荐剂量
WB: 1:500-1:2000
抗体种类
Monoclonal
宿主来源Mouse
构建方式This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD3 epsilon / CD3e (rh CD3 epsilon / CD3e; TMPY-01191; NP_000724.1; Met1-Asp126). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS with 10% Trehalose, 0.02% Tween 80, pH7.0
研究背景T-cell surface glycoprotein CD3 epsilon chain, also known as CD3E, is a single-pass type I membrane protein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. The CD3 epsilon subunit of the T cell receptor (TCR) complex contains two defined signaling domains, a proline-rich sequence and an immune tyrosine activation motifs (ITAMs), and this complex undergoes a conformational change upon ligand binding that is thought to be important for the activation of T cells. In the CD3 epsilon mutant mice, all stages of T cell development and activation that are TCR-dependent were impaired, but not eliminated, including activation of mature naïve T cells with the MHCII presented superantigen, staphylococcal enterotoxin B, or with a strong TCR cross-linking antibody specific for either TCR-Cbeta or CD3 epsilon. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. Homozygous mutations in CD3D and CD3E genes lead to a complete block in T-cell development and thus to an early-onset severe combined immunodeficiency phenotype.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Human CD3 epsilon / CD3e Protein (TMPY-01191)
抗原种属
Human
研究领域
ITIM/ITAM Immunoreceptors and Related Molecules
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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关键词

CD3-TCR complexCD3e molecule, epsilon

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