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Anti-CD3 epsilon/CD3e Antibody (2D709)
还可以产品编号 TMAY-01397
Anti-CD3 epsilon/CD3e Antibody (2D709) 是一种 Mouse 抗体，靶向 CD3 epsilon/CD3e。Anti-CD3 epsilon/CD3e Antibody (2D709) 可用于 WB。
Anti-CD3 epsilon/CD3e Antibody (2D709)
Anti-CD3 epsilon/CD3e Antibody (2D709)
还可以产品编号 TMAY-01397
Anti-CD3 epsilon/CD3e Antibody (2D709) 是一种 Mouse 抗体，靶向 CD3 epsilon/CD3e。Anti-CD3 epsilon/CD3e Antibody (2D709) 可用于 WB。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-CD3 epsilon/CD3e Antibody (2D709) is a Mouse antibody targeting CD3 epsilon/CD3e. Anti-CD3 epsilon/CD3e Antibody (2D709) can be used in WB. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 2D709 |
| 交叉反应 | Human |
| 验证活性 | Anti-CD3E mouse monoclonal antibody at 1:500 dilution. -Lane A: Jurkat Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Mouse IgG (H+L)/HRP at 1/10000 dilution. -Developed using the ECL technique. -Performed under reducing conditions. -Predicted band size:23 kDa. -Observed band size:23 kDa |
| 应用 | WB |
| 推荐剂量 | WB: 1:500-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD3 epsilon / CD3e (rh CD3 epsilon / CD3e; TMPY-01191; NP_000724.1; Met1-Asp126). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS with 10% Trehalose, 0.02% Tween 80, pH7.0 |
| 研究背景 | T-cell surface glycoprotein CD3 epsilon chain, also known as CD3E, is a single-pass type I membrane protein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. The CD3 epsilon subunit of the T cell receptor (TCR) complex contains two defined signaling domains, a proline-rich sequence and an immune tyrosine activation motifs (ITAMs), and this complex undergoes a conformational change upon ligand binding that is thought to be important for the activation of T cells. In the CD3 epsilon mutant mice, all stages of T cell development and activation that are TCR-dependent were impaired, but not eliminated, including activation of mature naïve T cells with the MHCII presented superantigen, staphylococcal enterotoxin B, or with a strong TCR cross-linking antibody specific for either TCR-Cbeta or CD3 epsilon. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. Homozygous mutations in CD3D and CD3E genes lead to a complete block in T-cell development and thus to an early-onset severe combined immunodeficiency phenotype.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human CD3 epsilon / CD3e Protein (TMPY-01191) |
| 抗原种属 | Human |
| 研究领域 | ITIM/ITAM Immunoreceptors and Related Molecules |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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