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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-AATF Polyclonal Antibody

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货号 TMAB-02134

Anti-AATF Polyclonal Antibody 是一种 Rabbit 抗体，靶向 AATF。Anti-AATF Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-AATF Polyclonal Antibody

Anti-AATF Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-02134

Anti-AATF Polyclonal Antibody 是一种 Rabbit 抗体，靶向 AATF。Anti-AATF Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-AATF Polyclonal Antibody is a Rabbit antibody targeting AATF. Anti-AATF Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat,Pig,Cow,Horse,Rabbit,GuineaPig)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus, nucleolus.
组织特异性Ubiquitously expressed. Expressed at high levels in brain, heart, kidney, placenta and thymus.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008]
抗原信息
免疫原
KLH conjugated synthetic peptide: human AATF
抗原种属
Human
基因名称
AATF
基因ID
26574
蛋白名称
Protein AATF
Uniprot ID
Q9NY61
功能
May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.
化学信息
分子量Theoretical: 63 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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