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顶部产品介绍偶联与修饰抗原信息储存和溶解信息计算器

Anti-BRCA1 Monoclonal Antibody (8A852)

Synonyms: RNF53, PSCP, PPP1R53, PNCA4, IRIS, BROVCA1, BRCC1, BRCAI
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Anti-BRCA1 Monoclonal Antibody (8A852) 是一种 Mouse 抗体，靶向 BRCA1。Anti-BRCA1 Monoclonal Antibody (8A852) 可用于 IHC。

Anti-BRCA1 Monoclonal Antibody (8A852)

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Rating icon 还可以
货号 TMAT-0180

别名 RNF53, PSCP, PPP1R53, PNCA4, IRIS, BROVCA1, BRCC1, BRCAI

Anti-BRCA1 Monoclonal Antibody (8A852) 是一种 Mouse 抗体，靶向 BRCA1。Anti-BRCA1 Monoclonal Antibody (8A852) 可用于 IHC。

Anti-BRCA1 Monoclonal Antibody (8A852)
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产品介绍

生物活性
产品描述
Anti-BRCA1 Monoclonal Antibody (8A852) is a Mouse antibody targeting BRCA1. Anti-BRCA1 Monoclonal Antibody (8A852) can be used in IHC.
别名
RNF53, PSCP, PPP1R53, PNCA4, IRIS, BROVCA1, BRCC1, BRCAI
Ig Type
IgG1
克隆号
8A852
反应种属
Human
应用IHC
推荐剂量
IHC: 1/200-1/1000
抗体种类
Monoclonal
宿主来源Mouse
构建方式Hybridoma Monoclonal Antibody
纯化方式Purified by protein A or protein G
性状Liquid
缓冲液PBS with 0.05% sodium azide
浓度1 mg/ml
研究背景This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Purified recombinant fragment of human BRCA1 (AA: 229-335) expressed in E. Coli.
抗原种属
Human
基因名称
BRCA1
基因ID
672
蛋白名称
Breast cancer type 1 susceptibility protein
Uniprot ID
P38398
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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