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Anti-Nicastrin Antibody-FITC (4B647)
还可以产品编号 TMAY-01719F
Anti-Nicastrin Antibody-FITC (4B647) 是一种 FITC-conjugated Rabbit 抗体，靶向 Nicastrin。Anti-Nicastrin Antibody-FITC (4B647) 可用于 FCM。
Anti-Nicastrin Antibody-FITC (4B647)
Anti-Nicastrin Antibody-FITC (4B647)
还可以产品编号 TMAY-01719F
Anti-Nicastrin Antibody-FITC (4B647) 是一种 FITC-conjugated Rabbit 抗体，靶向 Nicastrin。Anti-Nicastrin Antibody-FITC (4B647) 可用于 FCM。
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抗原信息
| 产品描述 | Anti-Nicastrin Antibody-FITC (4B647) is a FITC-conjugated Rabbit antibody targeting Nicastrin. Anti-Nicastrin Antibody-FITC (4B647) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 4B647 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of NCSTN on HepG2 cells. |
| 应用 | FCM |
| 推荐剂量 | 10 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human Nicastrin / NCSTN (rh Nicastrin / NCSTN; TMPY-01297; NP_056146.1; Met1-Glu669) and conjugated with FITC under optimum conditions, the unreacted FITC was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| 研究背景 | Nicastrin (NCST, or NCT), a single-pass membrane glycoprotein that harbors a large extracellular domain, is an essential component of the gamma-secretase complex. Several lines of evidence indicate that the members of these complexes could also contribute to the control of cell death. NCT controls cell death via phosphoinositide 3-kinase/Akt and p53-dependent pathways and that this function remains independent of the activity and molecular integrity of the gamma-secretase complexes. Increasing pieces of evidence have shown that Nicastrin/NCSTN plays a crucial role in gamma-cleavage of the amyloid precursor protein (APP). The glycoprotein Nicastrin is an essential component of the gamma-secretase complex, a high molecular weight complex that also contains the presenilin proteins, Aph-1 and Pen-2. The gamma-secretase complex is not only involved in APP processing but also in the processing of an increasing number of another type I integral membrane proteins. As the largest subunit of the gamma-secretase complex, Nicastrin plays a crucial role in its activation. Inhibition of NCSTN demonstrated an altered gamma-cleavage activity, suggesting its potential implication in developing Alzheimer's disease (AD). Besides, Nicastrin can function to maintain epithelial to mesenchymal transition during breast cancer progression. Anti-nicastrin polyclonal and monoclonal antibodies were able to decrease notch1 and vimentin expression and reduced the invasive capacity of breast cancer cells in vitro. |
| 偶联 | FITC |
| 其他可选修饰符 | Unconjugated/PE |
| 可提供抗体种类 | 3 |
| 免疫原 | Recombinant Human Nicastrin / NCSTN protein (TMPY-01297) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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