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TC-O 9311

Name: TC-O 9311
Brand: TargetMol
SKU: T4626L
Price: 116 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: TCO-9311, TC-O-9311, TC-O9311, TCO9311, TC-O 9311, TCO 9311

货号 T4626LCas号 444932-31-4 一键复制产品信息纯度: 99.84%

很棒

TC-O 9311是一种孤儿 G 蛋白偶联受体 139 激动剂，EC50值为 39 nM。

TC-O 9311

一键复制产品信息

很棒

纯度: 99.84%

货号 T4626LCas号 444932-31-4

别名 TCO-9311, TC-O-9311, TC-O9311, TCO9311, TC-O 9311, TCO 9311

TC-O 9311是一种孤儿 G 蛋白偶联受体 139 激动剂，EC50值为 39 nM。

规格	价格	库存
1 mg	¥ 116	现货
5 mg	¥ 273	现货
10 mg	¥ 448	现货
25 mg	¥ 826	现货
50 mg	¥ 1,380	现货
100 mg	¥ 1,980	现货
1 mL x 10 mM (in DMSO)	¥ 295	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.84%

颜色: 白色

性状: Solid

资源下载: COA LCMS HNMR产品操作手册

产品介绍

TC-O 9311 AI Summary

TC-O 9311 exhibits agonist activity at the human GPR139 receptor, as assessed through calcium mobilization using the FLIPR assay, with an Emax value of 125.0% and an EC50 value of 43.0 nM. It also shows antiviral activity against SARS-CoV-2, inhibiting virus-induced cytotoxicity in Caco-2 cells with an inhibition rate of 11.84% at 10 µM concentration after 48 hours, and demonstrating a 0.32% inhibition rate in VERO-6 cells under similar conditions. Furthermore, it inhibits SARS-CoV-2 3CL-Pro protease by 17.36% at 20µM in a FRET-based assay. In enzymatic assays, TC-O 9311 shows a 9.39% inhibition of human HDAC6 with a commercial peptide substrate, but only -0.28% inhibition with a custom peptide substrate. Incucyte cell viability assays revealed varied bioactivities, with HEK293T cell growth rates ranging from 0.01 to 0.97, U2OS cell growth rates from -1.0 to 1.0, and human fibroblast cells showing growth rates of 0.64 and 0.93, indicating both inhibitory and stimulatory effects on different cell lines. The compound influences protein stability in a domain-specific manner, decreasing the thermal stability of domains like N44-E168, M626-G740, M1-L298, M26-R383, and G861-E979 while not altering the E122-S403 domain and increasing stability for domains like M1-K294, P449-E759, and M1-S360. Additionally, TC-O 9311 shows bioactivity in GPCR beta-arrestin recruitment assays across various targets such as GPR119, C5AR1, AGTR1, ADGRF1, CX3CR1, ADRA2A, FFAR4, S1PR1, GLP1R, ADRB2, FPR2, GPR35, and APLNR, with both agonistic and inhibitory effects, indicating a complex pharmacological profile..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	TC-O 9311 (TCO-9311) is an effective agonist of GPR139 (EC50 = 39 nM in CHO-K1 cells expressing human GPR139).
靶点活性	GPR139:EC50 = 39 nM (in CHO-K1 cells)
别名	TCO-9311, TC-O-9311, TC-O9311, TCO9311, TC-O 9311, TCO 9311

化学信息

分子量	365.38
分子式	C₂₀H₁₉N₃O₄
CAS No.	444932-31-4
Smiles	COc1cc(OC)cc(c1)C(=O)NNC(=O)Nc1cccc2ccccc12
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 125 mg/mL (342.11 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.95 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7369 mL	13.6844 mL	27.3688 mL	136.8438 mL
5 mM	0.5474 mL	2.7369 mL	5.4738 mL	27.3688 mL
10 mM	0.2737 mL	1.3684 mL	2.7369 mL	13.6844 mL
20 mM	0.1368 mL	0.6842 mL	1.3684 mL	6.8422 mL
50 mM	0.0547 mL	0.2737 mL	0.5474 mL	2.7369 mL
100 mM	0.0274 mL	0.1368 mL	0.2737 mL	1.3684 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。