Anti-FYN Antibody (6E340)

Name: Anti-FYN Antibody (6E340)
Brand: TargetMol
SKU: TMAH-00466
Rating: 4.5 (1 reviews)

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产品编号 TMAH-00466

别名 Tyrosine-protein kinase Fyn, Src-like kinase, SLK, Proto-oncogene Syn, Proto-oncogene c-Fyn, p59-Fyn, EC 2.7.10.2

Anti-FYN Antibody (6E340) 是一种抗体，靶向 FYN。Anti-FYN Antibody (6E340) 可用于 ELISA, IHC。

Anti-FYN Antibody (6E340)

还可以

产品编号 TMAH-00466 别名 Tyrosine-protein kinase Fyn, Src-like kinase, SLK, Proto-oncogene Syn, Proto-oncogene c-Fyn, p59-Fyn, EC 2.7.10.2

Anti-FYN Antibody (6E340) 是一种抗体，靶向 FYN。Anti-FYN Antibody (6E340) 可用于 ELISA, IHC。

规格	价格	库存	数量
50 μL	¥ 1,315	5日内发货
100 μL	¥ 2,185	5日内发货

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产品描述	Anti-FYN Antibody (6E340) is an antibody targeting FYN. Anti-FYN Antibody (6E340) can be used in ELISA, IHC.
别名	Tyrosine-protein kinase Fyn, Src-like kinase, SLK, Proto-oncogene Syn, Proto-oncogene c-Fyn, p59-Fyn, EC 2.7.10.2
Ig Type	Rabbit IgG
克隆号	6E340
交叉反应	Human
验证活性	1. IHC image of TMAH-00466 diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. 2. IHC image of TMAH-00466 diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
应用	ELISA, IHC
推荐剂量	IHC:1:50-1:200.
抗体种类	Monoclonal
亚细胞定位	Cytoplasm. Nucleus. Cell membrane. Note=Present and active in lipid rafts. Palmitoylation is crucial for proper trafficking.
构建方式	Recombinant Antibody
纯化方式	Affinity-chromatography
性状	Liquid
缓冲液	Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景	Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1. In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling.