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Anti-FBXO45 Polyclonal Antibody
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产品编号 TMAB-00663
别名 hFbxo45, fbxo45, FBX45, FBSP1, F-box/SPRY domain-containing protein 1, F box protein 45
Anti-FBXO45 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 FBXO45。Anti-FBXO45 Polyclonal Antibody 可用于 WB。
Anti-FBXO45 Polyclonal Antibody
Anti-FBXO45 Polyclonal Antibody
还可以产品编号 TMAB-00663 别名 hFbxo45, fbxo45, FBX45, FBSP1, F-box/SPRY domain-containing protein 1, F box protein 45
Anti-FBXO45 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 FBXO45。Anti-FBXO45 Polyclonal Antibody 可用于 WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,160 | 5日内发货 | |
| 100 μL | ¥ 1,960 | 5日内发货 |
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产品介绍
生物活性
抗原信息
化学信息
| 产品描述 | Anti-FBXO45 Polyclonal Antibody is a Rabbit antibody targeting FBXO45. Anti-FBXO45 Polyclonal Antibody can be used in WB. |
| 疾病造模方案 | |
| 别名 | hFbxo45, fbxo45, FBX45, FBSP1, F-box/SPRY domain-containing protein 1, F box protein 45 |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | 1. Sample: Intestine (Mouse) Lysate at 40 μg Primary: Anti-FBXO45 (TMAB-00663) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 31 kDa Observed band size: 31 kDa 2. Sample: Lane 1: Human A431 cell lysates Lane 2: Human MCF-7 cell lysates Lane 3: Human U251 cell lysates Lane 4: Human K562 cell lysates Lane 5: Human Jurkat cell lysates Primary: Anti-FBXO45 (TMAB-00663) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 31 kDa Observed band size: 30 kDa |
| 应用 | |
| 推荐剂量 | WB: 1:500-2000 |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Cell junction > synapse > postsynaptic cell membrane. Cell junction > synapse > presynaptic cell membrane. |
| 构建方式 | Polyclonal Antibody |
| 纯化方式 | Protein A purified |
| 性状 | Liquid |
| 缓冲液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 浓度 | 1 mg/mL |
| 研究背景 | Belonging to the F-box family of proteins, FBXO45 is a 286 amino acid protein that contains one C-terminal F-box domain. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein)-type E3 ubiquitin ligase complex and are involved in substrate recognition and protein recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular mechanisms, including the cell cycle, the immune response, signaling cascades and developmental processes. They function by targeting proteins, such as cyclins, cyclin-dependent kinase inhibitors, I˚B-å and ∫-catenin, for degradation by the proteasome after ubiquitination. Via its F-box domain, FBXO45 can directly interact with Skp1 p19 and CUL-1. FBXO45 has been shown to be an estrogen-induced gene. |
| 免疫原 | KLH conjugated synthetic peptide: human FBXO45 |
| 抗原种属 | Human |
| 基因名称 | FBXO45 |
| 基因ID | |
| 蛋白名称 | F-box/SPRY domain-containing protein 1 |
| Uniprot ID | |
| 功能 | Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (By similarity). Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May controls synaptic activity by controlling UNC13A via ubiquitin dependent pathway (By similarity). Specifically recognizes TP73, promoting its ubiquitination and degradation. |
| 分子量 | Theoretical: 31 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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