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TN7122
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Micromarin F
E-Methylarnottinin,5'-hydroxylosthole
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Others |
Others |
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Micromarin F (E-Methylarnottinin) 是从 Micromelum minutum Wight et Arn 的茎中提取的香豆素衍生物。 |
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T22286
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Cyanosafracin B
Cyanoquinonamine,氰基番红菌素 B,CBR28-1
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Others |
Others |
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Cyanosafracin B (Cyanoquinonamine) 是一种合成 Phthalascidin Pt-650 及 Ecteinascidin ET-743 的起始原料。 |
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TN3029
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4-(Ethoxymethyl)phenol
p-Hydroxybenzyl Et ether
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Antioxidant |
oxidation-reduction |
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4-(Ethoxymethyl)phenol (p-Hydroxybenzyl Et ether) 是一种从 Amburana cearensis 中提取的小分子化合物，具有细胞毒性和抗氧化会活性。 |
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T3019
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Physcion
大黄素甲醚,Physcione,Parietin,Rheochrysidin
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Dehydrogenase;
Antibacterial |
Metabolism;
Microbiology/Virology |
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Physcion (Physcione) 是一种从中药大黄中分离的蒽醌，作为 6-磷酸葡萄糖酸脱氢酶的抑制剂，IC50和 Kd 值分别为 38.5 μM 和 26.0 μM。它具有通便、保肝、抗炎、抗菌、抗增殖、抗肿瘤作用。 |
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T36914
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2-Hydroxyanthraquinone
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Others |
Others |
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2-Hydroxyanthraquinone 是一种天然产物，显示出抗肿瘤和免疫抑制活性。 |
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T5757
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Loganetin
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Antibacterial |
Microbiology/Virology |
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Loganetin 是无毒的天然产物，来源于Cornus officinalis Sieb. et Zucc.，可用于耐多药革兰氏阴性菌感染的研究。 |
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T37886
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1-Heptadecanol
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Antibacterial |
Microbiology/Virology |
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1-Heptadecanol 是分离自Solena amplexicaulis 的长链伯醇，显示出抗菌活性。 |
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T37709
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2,2,2-Trichloroethanol
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Potassium Channel;
Endogenous Metabolite |
Membrane transporter/Ion channel;
Metabolism |
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2,2,2-Trichloroethanol 是非经典的 K2P 通道 TREK-1和 TRAAK 的激动剂。 |
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T34440
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Rubricauloside
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Rubricauloside is a coumarin-glycoside extracted from the roots of Peucedanum rubricaule Shan et Shch. |
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T78484
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Xanthohumol C
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Xanthohumol C，一种从Humulus lupulus的啤酒花中分离得到的异戊二烯基查尔酮。 |
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T11150
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Ecteinascidin 770
Ecteinascidine 770,Et-770
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Others |
Others |
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Ecteinascidin 770 (ET-770) inhibits U373MG cells and is a 1,2,3, 4-tetrahydroisoquinoline alkaloid with strong anticancer activity.IC50 is 4.83 nM. |
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TN1636
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Eupteleasaponin I
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Others |
Others |
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Eupteleasaponin I is a natural product from Euptelea polyandra Sieb. et Zucc. |
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TN3632
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(-)-Chelidonine
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Others |
Others |
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(-)-Chelidonine is a natural product from Glaucium squamigerum KAR. et KIR. |
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TN2751
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2-Deacetoxydecinnamoyltaxinine J
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Others |
Others |
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2-Deacetoxydecinnamoyltaxinine J is a natural product from Taxus cuspidta Sibe et Zucc. |
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TN5122
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Taxuspine B
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Others |
Others |
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Taxuspine B is a natural product from the Japanese yew Taxus cuspidata Sieb. et Zucc. |
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TN5123
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Taxuspine W
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Others |
Others |
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Taxuspine W is a natural product from the Japanese yew Taxus cuspidata Sieb. et Zucc. |
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TN3082
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5,6-Dimethoxy-2-isopropenylbenzofuran
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Others |
Others |
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5,6-Dimethoxy-2-isopropenylbenzofuran is a natural product from Ligularia stenocephala MATSUM. et KOIDZ. |
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TN2544
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1-Hydroxymethyl-beta-carboline glucoside
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Others |
Others |
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1-Hydroxymethyl-beta-carboline glucoside is a natural product from Picrasmae Ramulus et Folium. |
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TN2439
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(2-Methylbutyryl)shikonin
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Others |
Others |
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(2-Methylbutyryl)shikonin is a natural product from Lithospermum erythrorhizon Sieb. et Zucc. |
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TN2528
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1-Deacetylnimbolinin B
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Others |
Others |
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1-Deacetylnimbolinin B is a natural product from Melia toosendan Sieb. et Zucc. |
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TJS1226
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7-(deoxyadenosin-N(6)-yl)aristolactam I
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Others |
Others |
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7-(deoxyadenosin-N(6)-yl)aristolactam I是一种来自马兜铃草药的天然化合物。 |
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T83462
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11-O-Syringylbergenin
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11-O-Syringylbergenin为自龙骨草全草中分离出的岩白菜素类衍生物。 |
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T36438
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Sporogen-AO 1
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Sporogen-AO 1 is a fungal metabolite originally isolated fromA. oryzaethat has diverse biological activities.1,2,3,4,5It inhibits HIV-1 Tat transactivation in a cell-based assay with an IC50value of 15.8 μM.4Sporogen-AO 1 is cytotoxic to HeLa, KB, and NCI H187 cancer cells (IC50s = 8.3, 9, and 5.1 μM, respectively).2,5It is active againstC. albicans(MIC = 4 mM).3
1.Tanaka, S., Wada, K., Marumo, S., et al.Structure of sporogen-ao 1, a sporogenic substance of Aspergillus oryzaeTetrahedron Lett.25(... |
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T36295
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Echistatin TFA
|
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Echistatin TFA, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of αIIbβ3, αvβ3 and α5β1[1][2][3][4].
[1]. J Musial, et al. Inhibition of platelet adhesion to surfaces of extracorporeal circuits by disintegrins. RGD-containing peptides from viper venoms. Circulation. 1990 Jul;82(1):261-73.[2]. ... |
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T37345
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5,7-Dihydroxycoumarin
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Antibacterial |
Microbiology/Virology |
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5,7-Dihydroxycoumarin 是分离自Macaranga triloba 花序的香豆素，具有抗菌活性。 |
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T37962
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Paeoniflorgenin
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Paeoniflorgenin is a deglucosylated metabolite of Paeoniflorin[1].
[1]. Hsiu SL, et, al. A deglucosylated metabolite of paeoniflorin of the root of Paeonia lactiflora and its pharmacokinetics in rats. Planta Med. 2003 Dec; 69(12): 1113-8. |
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T37609
|
(rel)-Asperparaline A
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Aspergillimide is a fungal metabolite originally isolated from A. japonicus.1 It reduces nicotinic acetylcholine receptor (nAChR) peak and slowly-desensitizing amplitudes induced by acetylcholine in silkworm (B. mori) larval neurons (IC50s = 20.2 and 39.6 nM, respectively) but has no effect on chicken α3β4-, α4β2-, and α7-containing nAChRs.2 Dietary administration of aspergillimide A (10 μg/g of diet) induces paralysis in silkworm fourth instar larvae.1 Aspergillimide A (10 and 20 mg/kg) reduces... |
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T36000
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3-Hydroxyterphenyllin
|
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3-Hydroxyterphenyllin is a p-terphenyl fungal metabolite originally isolated from A. candidus that has diverse biological activities, including antioxidant, antiproliferative, antibacterial, and antiviral properties.1,2,3,4 It has a 96% scavenging effect on 2,2-diphenyl-1-picrylhydrazyl radicals when used at a concentration of 100 μg/ml.2 3-Hydroxyterphenyllin inhibits the growth of HeLa cervical, A549 lung, and HepG2 liver cancer cells (IC50s = 23, 36, and 32 μM, respectively), as well as methi... |
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T37690
|
Phenylpyropene A
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Phenylpyropene A is a fungal metabolite originally isolated from P. griseofulvum that has enzyme inhibitory and insecticidal activities.1,2,3 It inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 0.8 μM).1 Phenylpyropene A inhibits diacylglycerol acyltransferase (DGAT) in rat liver microsomes (IC50 = 78.7 μM). It induces mortality in 100% of M. persicae when used at a concentration of 5 ppm.3
|1. Kwon, O.E., Rho, M.C., Song, H.Y., et al. Phenylpyropene A and B, new inhibitors of ... |
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T35667
|
Napyradiomycin A1
Napyradiomycin A1
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Napyradiomycin A1is a fungal metabolite originally isolated fromC. rubraand has diverse biological activities.1,2It is active againstS. aureus,M. luteus,B. anthracis,C. bovis, andM. smegmatis(MICs = 1.56-12.5 μg/ml).1Napyradiomycin A1is an estrogen receptor antagonist (IC50= 4.2 μM in rat uterine homogenates).2It also inhibits mitochondrial NADH:ubiquinone oxidoreductase (complex I) and succinate:ubiquinone oxidoreductase (complex II) activities in bovine heart homogenates (IC50s = 20 and 9.7 μM... |
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T38069
|
Aquastatin A
|
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Aquastatin A is a fungal metabolite originally isolated fromF. aquaeductuumthat has diverse biological activities.1It is active againstS. aureus(MIC = 32 μg/ml) and inhibits enoyl-acyl carrier protein reductase (Fabl; IC50= 3.2 μM) andS. aureusfatty acid synthesis (IC50= 3.5 μM).2Aquastatin A also inhibits the Na+/K+-ATPase and H+/K+-ATPase (IC50s = 7.1 and 6.2 μM, respectively), as well as protein tyrosine phosphatase 1B (PTP1B; IC50= 0.19 μM).1,3
1.Hamano, K., Kinoshita-Okami, M., Minagawa, K.... |
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T36791
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Lysophosphatidylcholine 18:2
|
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1-Linoleoyl-2-hydroxy-sn-glycero-3-PC (LGPC) is a lysophospholipid containing linoleic acid at thesn-1 position that has been found in mouse heart, lung, liver, spleen, kidney, plasma, and serum.1Serum levels of LGPC decrease with increasing insulin resistance and dysglycemia in humans.2
1.Okudaira, M., Inoue, A., Shuto, A., et al.Separation and quantification of 2-acyl-1-lysophospholipids and 1-acyl-2-lysophospholipids in biological samples by LC-MS/MSJ. Lipid Res.55(10)2178-2192(2014) 2.Gall, ... |
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T36563
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(E)-Guggulsterone
|
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Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.1They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress.2,3Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hy... |
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T35750
|
Trypacidin
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Trypacidin is a fungal metabolite originally isolated fromA. fumigatus.1It is active againstB. subtilisandM. bovis(MICs = 12.5 and 1.25 μg/ml, respectively), as well asT. cruziandT. gondii(MICs = 5-10 and 10-20 μg/ml, respectively).1,2It reduces viability and induces lysis of A549 human lung cancer cells (IC50s = 7.4 μM for both).3Trypacidin increases survival in a mouse model ofT. gondiiinfection when administered in six doses of 12.5 mg/kg each.1
1.Balan, J., Ebringer, L., Nemec, P., et al.Ant... |
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T35609
|
19-O-Acetylchaetoglobosin A
|
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19-O-Acetylchaetoglobosin A is a fungal metabolite originally isolated fromC. globosumthat has actin polymerization inhibitory and cytotoxic activities.1,2It inhibits actin polymerization in a cell-free assay when used at a concentration of 2 μM.219-O-Acetylchaetoglobosin A (3.2, 10, and 32 μg/ml) is cytotoxic to HeLa cervical cancer cells.1
1.Umeda, M., Ohtsubo, K., Saito, M., et al.Cytotoxicity of new cytochalasans from Chaetomium globosumExperientia31(4)435-438(1975) 2.Sekita, S., Yoshihira, ... |
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T35761
|
Carviolin
|
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Carviolin is an anthraquinone fungal metabolite that has been found inZ. longicaudatawith immunosuppressive and antitrypanosomal activities.1,2It inhibits LPS- or concanavalin A-induced proliferation of mouse splenocytes (IC50s = 4 and 4.5 μg/ml, respectively).1Carviolin is active againstT. b. brucei(MIC = 41.66 μM).2
1.Fujimoto, H., Nakamura, E., Okuyama, E., et al.Six immunosuppressive features from an ascomycete, Zopfiella longicaudata, found in a screening study monitored by immunomodulatory... |
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T37451
|
Stachybotrysin B
|
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Stachybotrysin B is a fungal metabolite originally isolated from S. chartarum and has antiviral and anticancer activities.1,2 It has antiviral activity against HIV in SupT1 cells (IC50 = 19.2 μM).1 Stachybotrysin B is cytotoxic to K562, HeLa, and HL-60 cells (IC50s = 21.72, 39.63, and 18.5 μM, respectively).2
|1. Zhao, J., Feng, J., Tan, Z., et al. Stachybotrysins A-G, phenylspirodrimane derivatives from the fungus Stachybotrys chartarum. J. Nat. Prod. 80(6), 1819-1826 (2017).|2. Ma, X.-h., Zhen... |
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T36734
|
Methyl brevifolincarboxylate
|
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Methyl brevifolincarboxylate (Brevifolincarboxylic acid methyl ester) is a potent influenza virus PB2 cap-binding inhibitor. Methyl brevifolincarboxylate exhibits inhibitory activity against influenza virus A/Puerto Rico/8/34 (H1N1) and A/Aichi/2/68 (H3N2) with IC50s of 27.16 μM and 33.41 μM. Anti-oxidant activity[1][2].
Methyl brevifolincarboxylate exhibits significant DPPH radical scavenging activity with an IC50 value of 8.9 μM.
[1]. Wu QY, et al. Chromatographic fingerprint and the simultane... |
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T37452
|
Stephacidin B
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Stephacidin B is a fungal metabolite that has been found inA. ochraceus.1Dimeric stephacidin B is rapidly converted to a monomer, avrainvillamide ,in vitro.2Stephacidin B is cytotoxic to a variety of cancer cells, including testosterone-independent PC3 and -sensitive LNCaP prostate cancer cells (IC50s = 0.37 and 0.06 μM, respectively) and estradiol-independent SK-BR-3 and -sensitive MCF-7 breast cancer cells (IC50s = 0.32 and 0.27 μM, respectively).1It induces apoptosis in HepG2 and Huh7 hepatoc... |
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T36329
|
Terpendole I
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Terpendole I is a fungal metabolite that has been found in A. yamanashiensis.1 It is a weak inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 145 μM) and is active against the bacteria B. cereus and B. subtilis (MICs = 100 μg/ml for both) but not S. aureus, P. aeruginosa, or K. pneumoniae (MICs = >200 μg/ml for all) or the fungus C. albicans (MIC = 200 μg/ml).1,2 It is cytotoxic to HeLa cells with an IC50 value of 52.6 μM.3
|1. Tomoda, H., Tabata, N., Yang, D.-J., et al. Ter... |
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T35911
|
Piliformic Acid
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Piliformic acid is a fungal metabolite that has been found inN. pseudotrichiaand has diverse biological activities.1,2It is cytotoxic to BC-1 human breast cancer cells (IC50= 5 μg/ml).2Piloformic acid is active againstL. braziliensisamastigotes (IC50= 78.5 μM). It is also active against the plant pathogenic fungiC. gloeosporioides(MIC = 292 μM).1
1.Elias, L.M., Fortkamp, D., Sartori, S.B., et al.The potential of compounds isolated from Xylaria spp. as antifungal agents against anthracnoseBraz. J... |
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T36448
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(E)-Ajoene
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(E)-Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities.1,2,3,4It is active against Gram-positive and Gram-negative bacteria (MICs = 10-250 and 150->500 μg/ml, respectively) and fungi (MICs = 15-50 μg/ml).1(E)-Ajoene inhibits proliferation of a variety of cancer cells, including MDA-MB-231 breast, HeLa cervical, and WHCO1 esophageal cancer cells (IC50s = 18.6, 61, and 39.2 μM, respectively).2It also inhibits human glutathione reductase andT. cruzitrypanoth... |
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T38330
|
Collinin
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Collinin is a coumarin that has been found in Z. schinifolium and has diverse biological activities.1,2,3,4 It is active against drug-susceptible and -resistant strains of M. tuberculosis (MIC50s = 3.13-6.25 μg/ml).1 Collinin inhibits LPS-induced nitric oxide (NO) production (IC50 = 5.9 μM) and reduces COX-2 protein levels in RAW 264.7 cells.2 It completely inhibits aggregation of isolated rabbit platelets induced by arachidonic acid , collagen, or platelet activating factor (PAF) when used at a... |
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T36915
|
21-Deoxycortisol
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21-Deoxycortisol is a corticosteroid metabolite of 17-hydroxyprogesterone produced in the adrenal glandvia11-hydroxylation by 11β-hydroxylase.1,2Serum levels of 21-deoxycortisol are elevated in patients with congenital adrenal hyperplasia that are heterozygous for mutations inCYP2A21, the gene encoding steroid 21-hydroxylase, and have been used as a biomarker for the detection of 21-hydroxylase deficiencies.
1.Fiet, J., Villette, J.-M., Galons, H., et al.The application of a new highly-sensitive... |
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T35779
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Oosporein
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Oosporein is a mycotoxin that has been found inBeauveriaand has diverse biological activities.1,2It is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of 4.23 and 10.43 μM, respectively.3Oosporin induces lethality in day-old cockerels (LD50= 6.12 mg/kg).4It inhibits Na+/K+-, Ca2+-, and Mg2+-ATPase activities by 27, 52, and 100%, respectively, in equine erythrocyte ghosts when used at a concentration of 200 μg/ml.2Oosporein inhibits herpes simplex 1 (HSV-1), ... |
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T38258
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Phanerosporic Acid
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Phanerosporic acid is a fungal secondary metabolite originally isolated from P. chrysosporum that has antibacterial activity against B. cereus, B. subtilis, and E. coli and antifungal activity against S. cerevisiae, A. niger, O. ulmi, U. maydis, C. cucmerinum, C. cladosporioides, and B. cinerea.1 It has been used in the synthesis of macrolide derivatives.References1. Arnone, A., Assante, G., Nasini, G., et al. Phanerosporic acid, a β-resorcylate obtained from Phanerochaete chrysosporium. Phytoch... |
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T36226
|
Beauveriolide I
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Beauveriolide I is a cyclodepsipeptide that has been found inBeauveriaand an inhibitor of lipid droplet formation.1It inhibits lipid droplet formation when used at concentrations of 3 and 10 μM, as well as inhibits cholesterol synthesis (IC50= 0.78 μM), in primary mouse peritoneal macrophages.1,2Beauveriolide I also inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in mouse macrophage membranes (IC50= 6 μM).2
1.Namatame, I., Tomoda, H., Si, S., et al.Beauveriolides, specific i... |
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T37272
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9(S),12(S),13(S)-TriHOME
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9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.1,59(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50= 28.7 μg/ml).2It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50= 40.95 μM).3In vivo, 9(S),12(S),13(S)-TriHOME... |
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T36893
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4-oxo Withaferin A
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4-oxo Withaferin A is a derivative of the steroidal lactone withaferin A that has anticancer activity.1 It is cytotoxic to A2780 ovarian cancer cells and carboplatin-resistant A2780 (A2780/CP70) cells (IC50s = 7.3 and <1 μM, respectively) and is 4.4-fold selective for A2780 cells over non-cancerous ARPE19 cells.References1. Perestelo, N.R., Llanos, G.G., Reyes, C.P., et al. Expanding the chemical space of withaferin A by incorporating silicon to improve its clinical potential on human ovarian ca... |
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T36954
|
Nemorosone
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Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC50s = 3.1-6.3 μM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC50 = >40 μM).2 It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nem... |
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