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顶部生物活性储存和溶解信息计算器

Anti-MMP-2 Antibody (3D181)

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产品编号 TMAY-00229

别名 MMP-2, matrix metallopeptidase 2, GelA, Clg4a

Anti-MMP-2 Antibody (3D181) 是一种 Mouse 抗体，靶向 MMP-2。Anti-MMP-2 Antibody (3D181) 可用于 ELISA,FCM。

Anti-MMP-2 Antibody (3D181)

Anti-MMP-2 Antibody (3D181)

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Rating icon 还可以
产品编号 TMAY-00229 别名 MMP-2, matrix metallopeptidase 2, GelA, Clg4a

Anti-MMP-2 Antibody (3D181) 是一种 Mouse 抗体，靶向 MMP-2。Anti-MMP-2 Antibody (3D181) 可用于 ELISA,FCM。

规格价格库存数量
20 μL
¥ 590
5日内发货
100 μL
¥ 1,694
5日内发货
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产品介绍

生物活性
产品描述
Anti-MMP-2 Antibody (3D181) is a Mouse antibody targeting MMP-2. Anti-MMP-2 Antibody (3D181) can be used in ELISA,FCM.
别名MMP-2, matrix metallopeptidase 2, GelA, Clg4a
Ig Type
Mouse IgG2a
克隆号
3D181
交叉反应
Human
特异性
Human MMP-2
No cross-reactivity in ELISA with
Human MMP1
Human MMP7
Human MMP9
Human cell lysate (293 cell line)
验证活性
Flow cytometric analysis of Human MMP2 expression on MG63 cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), stained with purified anti-Human MMP2, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
应用ELISAFCM
推荐剂量
ELISA: 1:5000-1:10000; FCM: 1:25-1:100
抗体种类
Monoclonal
宿主来源Mouse
构建方式This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human MMP-2 (rh MMP-2; TMPY-01477; NP_004521.1; Met 1-Cys660). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS with 10% Trehalose, pH7.0
研究背景Matrix Metalloproteinase-2 (MMP-2) is an enzyme that degrades components of the extracellular matrix and thus plays a pivotal role in cell migration during physiological and pathological processes. MMP-2 expression is dependent on extracellular matrix metalloproteinase inducer (EMMPRIN), Her2/neu, growth factors, cytokines, and hormones. Pro-MMP-2 activation needs MT1-MMP and TIMP-2 contribution. MMP-2 is changed in distribution and increased in amount in the ventral cochlear nucleus after unilateral cochlear ablation. A low level of MMP-2 is linked to a favorable prognosis in patients with a hormone receptor-negative tumor, usually associated with high risk. As a zymogen requiring proteolytic activation for catalytic activity, MMP-2 has been implicated broadly in the invasion and metastasis of many cancer model systems, including human breast cancer (HBC). Blocking MMP-2 secretion and activation during breast carcinoma development may decrease metastasis. The detection of active MMP-2 alone or the rate of pro-MMP-2 and active MMP-2 is considered a very sensitive indicator of cancer metastasis. Modulation of MMP-2 expression and activation through specific inhibitors and activators may thus provide a new mechanism for breast cancer treatment.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Human MMP-2 protein (TMPY-01477)
抗原种属
Human
研究领域
Cancer Drug Targets
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

计算器

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关键词

MMP2MMP 2

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