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Anti-MMP-2 Antibody (3D181)
还可以产品编号 TMAY-00229
Anti-MMP-2 Antibody (3D181) 是一种 Mouse 抗体，靶向 MMP-2。Anti-MMP-2 Antibody (3D181) 可用于 ELISA,FCM。
Anti-MMP-2 Antibody (3D181)
Anti-MMP-2 Antibody (3D181)
还可以产品编号 TMAY-00229
Anti-MMP-2 Antibody (3D181) 是一种 Mouse 抗体，靶向 MMP-2。Anti-MMP-2 Antibody (3D181) 可用于 ELISA,FCM。
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抗原信息
| 产品描述 | Anti-MMP-2 Antibody (3D181) is a Mouse antibody targeting MMP-2. Anti-MMP-2 Antibody (3D181) can be used in ELISA,FCM. |
| Ig Type | Monoclonal Mouse IgG2a |
| 克隆号 | 3D181 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human MMP2 expression on MG63 cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), stained with purified anti-Human MMP2, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | ELISA,FCM |
| 推荐剂量 | ELISA: 1:5000-1:10000; FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human MMP-2 (rh MMP-2; TMPY-01477; NP_004521.1; Met 1-Cys660). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS with 10% Trehalose, pH7.0 |
| 研究背景 | Matrix Metalloproteinase-2 (MMP-2) is an enzyme that degrades components of the extracellular matrix and thus plays a pivotal role in cell migration during physiological and pathological processes. MMP-2 expression is dependent on extracellular matrix metalloproteinase inducer (EMMPRIN), Her2/neu, growth factors, cytokines, and hormones. Pro-MMP-2 activation needs MT1-MMP and TIMP-2 contribution. MMP-2 is changed in distribution and increased in amount in the ventral cochlear nucleus after unilateral cochlear ablation. A low level of MMP-2 is linked to a favorable prognosis in patients with a hormone receptor-negative tumor, usually associated with high risk. As a zymogen requiring proteolytic activation for catalytic activity, MMP-2 has been implicated broadly in the invasion and metastasis of many cancer model systems, including human breast cancer (HBC). Blocking MMP-2 secretion and activation during breast carcinoma development may decrease metastasis. The detection of active MMP-2 alone or the rate of pro-MMP-2 and active MMP-2 is considered a very sensitive indicator of cancer metastasis. Modulation of MMP-2 expression and activation through specific inhibitors and activators may thus provide a new mechanism for breast cancer treatment. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human MMP-2 protein (TMPY-01477) |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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