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2'-Deoxyguanosine

Name: 2'-Deoxyguanosine
Brand: TargetMol
SKU: T22218
Price: 136 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.86%

货号 T22218Cas号 961-07-9

别名 Guanine deoxyriboside, Deoxyguanosine, 2'-脱氧鸟苷

2'-Deoxyguanosine (Guanine deoxyriboside) 是一种嘌呤核苷，可被2'-dG-II家族的成员识别。2'-Deoxyguanosine 与衰老、突变和致癌有关，可被分子氧氧化。

2'-Deoxyguanosine

一键复制产品信息

很棒

纯度: 99.86%

货号 T22218 别名 Guanine deoxyriboside, Deoxyguanosine, 2'-脱氧鸟苷Cas号 961-07-9

2'-Deoxyguanosine (Guanine deoxyriboside) 是一种嘌呤核苷，可被2'-dG-II家族的成员识别。2'-Deoxyguanosine 与衰老、突变和致癌有关，可被分子氧氧化。

规格	价格	库存
100 mg	¥ 136	现货
500 mg	¥ 289	5日内发货
1 mL x 10 mM (in DMSO)	¥ 180	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.86%

颜色: 白色

性状: Solid

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资源下载:

COA HPLC HNMR 产品操作手册

产品介绍

2'-Deoxyguanosine AI Summary

2'-Deoxyguanosine exhibits a wide range of bioactivities, including potent antiviral effects against herpes simplex virus-1 (HSV-1), herpes simplex virus-2 (HSV-2), varicella zoster virus, and human cytomegalovirus. It shows antiproliferative effects on human leukemia cells and inhibits cellular replication in specific cancer cell lines such as Friend erythroleukemia and HGPRT- HL-60 cells with ID50 values of 0.29 mM and 0.49 mM, respectively. The compound demonstrates inhibitory activity against HSV-1 thymidine kinase with an ID50 value of 300.0 µM and displays selective inhibition of HIV replication in MT-4 cells with an ED50 of 158.0 µM, showing no cytotoxicity at a dose of CD50 > 500.0 µM (Selectivity Index = 3.1). Furthermore, 2'-Deoxyguanosine affects the activity of deoxycytidine kinase and deoxyguanosine kinase from Staphylococcus aureus. It modulates lipid storage in Drosophila S3 cells, inhibits Tau fibril formation, impacts lipid storage, inhibits chronic active B-cell receptor signaling, induces genotoxicity in HEK293T cells, and induces synthetic lethality in tumor cells producing 2HG. The compound also inhibits TDP1 activity and shows activity against Vaccinia Orthopoxvirus. Additionally, it significantly inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3 transfected CHO cells. In cytotoxicity assays, 2'-Deoxyguanosine shows relatively low toxicity in various cell lines, with an IC50 greater than 250,000 nM. It also exhibits an activity level of 65% in human erythrocyte purine nucleoside phosphorylase assays. Overall, 2'-Deoxyguanosine demonstrates diverse biological activities, making it a compound of interest for further research in antiviral therapeutics, cancer treatment, and other bioactive applications..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	2'-Deoxyguanosine (Guanine deoxyriboside) is a purine nucleoside that is recognized by members of the 2'-dG-II family.2'-Deoxyguanosine has been associated with aging, mutation, and carcinogenesis, and is oxidized by molecular oxygen.
别名	Guanine deoxyriboside, Deoxyguanosine, 2'-脱氧鸟苷

化学信息

分子量	267.24
分子式	C₁₀H₁₃N₅O₄
CAS No.	961-07-9
Smiles	O=C1C2=C(N(C=N2)[C@@H]3O[C@H](CO)[C@@H](O)C3)NC(N)=N1
密度	2.08g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 100 mg/mL (374.2 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (14.97 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7420 mL	18.7098 mL	37.4195 mL	187.0977 mL
5 mM	0.7484 mL	3.7420 mL	7.4839 mL	37.4195 mL
10 mM	0.3742 mL	1.8710 mL	3.7420 mL	18.7098 mL
20 mM	0.1871 mL	0.9355 mL	1.8710 mL	9.3549 mL
50 mM	0.0748 mL	0.3742 mL	0.7484 mL	3.7420 mL
100 mM	0.0374 mL	0.1871 mL	0.3742 mL	1.8710 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

EndogenousMetabolite Endogenous Metabolite 2'-Deoxyguanosine

2'-Deoxyguanosine

2'-Deoxyguanosine