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Anti-Caspase-1 Antibody (4V493)
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产品编号 TMAC-00576
别名 p45, Interleukin-1 β convertase (IL-1BC), Interleukin-1 beta convertase (IL-1BC), Interleukin-1 b-converting enzyme (ICE, IL1BCE, IL-1BC, IL1BC, IL-1 β-converting enzyme), IL-1 b-converting enzyme), Caspase-1, CASP 1
Anti-Caspase-1 Antibody (4V493) 是一种 Rabbit 抗体，靶向 Caspase-1。Anti-Caspase-1 Antibody (4V493) 可用于 WB,IHC,FCM。
Anti-Caspase-1 Antibody (4V493)
Anti-Caspase-1 Antibody (4V493)
还可以产品编号 TMAC-00576 别名 p45, Interleukin-1 β convertase (IL-1BC), Interleukin-1 beta convertase (IL-1BC), Interleukin-1 b-converting enzyme (ICE, IL1BCE, IL-1BC, IL1BC, IL-1 β-converting enzyme), IL-1 b-converting enzyme), Caspase-1, CASP 1
Anti-Caspase-1 Antibody (4V493) 是一种 Rabbit 抗体，靶向 Caspase-1。Anti-Caspase-1 Antibody (4V493) 可用于 WB,IHC,FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,495 | 5日内发货 | |
| 100 μL | ¥ 2,480 | 5日内发货 |
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| 产品描述 | Anti-Caspase-1 Antibody (4V493) is a Rabbit antibody targeting Caspase-1. Anti-Caspase-1 Antibody (4V493) can be used in WB,IHC,FCM. |
| 别名 | p45, Interleukin-1 β convertase (IL-1BC), Interleukin-1 beta convertase (IL-1BC), Interleukin-1 b-converting enzyme (ICE, IL1BCE, IL-1BC, IL1BC, IL-1 β-converting enzyme), IL-1 b-converting enzyme), Caspase-1, CASP 1 |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | 1. Western blot analysis of Caspase-1 on different lysates using anti-Caspase-1 antibody at 1/1,000 dilution. Positive control: Lane 1: THP-1, Lane 2: Jurkat. 2. Immunohistochemical analysis of paraffin-embedded human lung tissue using anti-Caspase-1 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human lung cancer tissue using anti-Caspase-1 antibody. Counter stained with hematoxylin. 4. Immunohistochemical analysis of paraffin-embedded mouse liver tissue using anti-Caspase-1 antibody. Counter stained with hematoxylin. 5. Flow cytometric analysis of Hela cells with Caspase-1 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody. |
| 应用 | |
| 推荐剂量 | WB: 1:1000-2000; IHC: 1:50-200; FCM: 1:50-100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | Caspase-1, originally designated ICE (for IL-1 converting enzyme), is a member of the group of caspases with large prodomains. Caspase-1 promotes maturation of interleukin IL-1β and interleukin18 (IL-18) by proteolytic cleavage of precursor forms into biologically active pro-inflamatory cytokines. Active caspase-1, a (p20/p10)2 tetramer, is necessary and sufficient for cleavage of precursor IL-1 as well as for induction of apoptosis in some cell lines. The highly conserved family of caspases mediate many of the morphological and biochemical features of apoptosis, including structural dismantling of cell bodies and nuclei, fragmentation of genomic DNA, destruction of regulatory proteins and propagation of other pro-apoptotic molecules. The human Caspase-1 gene maps to chromosome 2q14 and encodes a cytoplasmic protein expressed in liver, heart, skeletal muscle kidney and testis. Caspase-1 has been implicated in inflammation, septic shock, and other situations such as wound healing and the growth of certain leukemias. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein |
| Uniprot ID |
| 分子量 | Theoretical: 45 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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