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FGIN-1-43

Name: FGIN-1-43
Brand: TargetMol
SKU: T22783
Price: 137 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.57%

货号 T22783Cas号 145040-29-5

FGIN-1-43 是一种有效的线粒体 DBI 受体特异性配体。

为众多的药物研发团队赋能，

让新药发现更简单！

FGIN-1-43

一键复制产品信息

很棒

纯度: 99.57%

货号 T22783Cas号 145040-29-5

FGIN-1-43 是一种有效的线粒体 DBI 受体特异性配体。

规格	价格	库存
2 mg	¥ 137	现货
5 mg	¥ 226	现货
10 mg	¥ 365	现货
25 mg	¥ 721	现货
50 mg	¥ 1,160	现货
100 mg	¥ 1,870	现货
200 mg	¥ 2,630	现货
1 mL x 10 mM (in DMSO)	¥ 242	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.57%

颜色: 黄色

性状: Solid

联系我们获取更多批次信息

资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

FGIN-1-43 AI Summary

FGIN-1-43 shows binding affinity against the mitochondrial DBI complex (peripheral benzodiazepine receptor) and exhibits inhibitory activity at a range of receptors, including GABA A, GABA B, glycine, glutamate, opiate, serotonin, dopamine, cholecystokinin, beta-adrenergic, alpha-adrenergic, and cannabinoid receptors in rat brain. It has demonstrated antineophobic activity in rats using the elevated plus maze test. Additionally, FGIN-1-43 exhibits bioactivity in various assays such as inhibition of HSD17B4, JMJD2E, Cytochrome P450 enzymes 2C19 and 3A4, ALDH1A1, and HPGD, along with enhancement of SMN2 splice variant expression and activation of Cytochrome P450 3A4. This compound also shows notable inhibitory activity against human HDAC6 enzyme, exhibiting -21.58% inhibition with a commercial peptide substrate. In antiviral assays, it inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells and shows potential as a protease inhibitor against SARS-CoV-2 3CL-Pro protease. This array of activities suggests that FGIN-1-43 may have significant pharmacological effects across various biological targets..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	FGIN-1-43 is a potent and specific ligand for the mitochondrial DBI receptor.

化学信息

分子量	487.5
分子式	C₂₈H₃₆Cl₂N₂O
CAS No.	145040-29-5
Smiles	C(C(N(CCCCCC)CCCCCC)=O)C1=C(NC=2C1=CC(Cl)=CC2)C3=CC=C(Cl)C=C3
密度	1.143g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 22.5 mg/mL (46.15 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0513 mL	10.2564 mL	20.5128 mL	102.5641 mL
5 mM	0.4103 mL	2.0513 mL	4.1026 mL	20.5128 mL
10 mM	0.2051 mL	1.0256 mL	2.0513 mL	10.2564 mL
20 mM	0.1026 mL	0.5128 mL	1.0256 mL	5.1282 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。