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Anti-CNDP1 Antibody (4P563)
还可以产品编号 TMAY-00227
别名 Cn1, carnosine dipeptidase 1 (metallopeptidase M20 family), AI746433
Anti-CNDP1 Antibody (4P563) 是一种 Rabbit 抗体，靶向 CNDP1。Anti-CNDP1 Antibody (4P563) 可用于 ELISA,ICC/IF。
Anti-CNDP1 Antibody (4P563)
Anti-CNDP1 Antibody (4P563)
还可以产品编号 TMAY-00227 别名 Cn1, carnosine dipeptidase 1 (metallopeptidase M20 family), AI746433
Anti-CNDP1 Antibody (4P563) 是一种 Rabbit 抗体，靶向 CNDP1。Anti-CNDP1 Antibody (4P563) 可用于 ELISA,ICC/IF。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 20 μL | ¥ 795 | 5日内发货 | |
| 100 μL | ¥ 2,284 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-CNDP1 Antibody (4P563) is a Rabbit antibody targeting CNDP1. Anti-CNDP1 Antibody (4P563) can be used in ELISA,ICC/IF. |
| 别名 | Cn1, carnosine dipeptidase 1 (metallopeptidase M20 family), AI746433 |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 4P563 |
| 交叉反应 | Human |
| 验证活性 | Immunofluorescence staining of Human CNDP1 in MCF7 cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, and incubated with rabbit anti-Human CNDP1 monoclonal antibody (1:60) at 37°C 1 hour. Then cells were stained with the Alexa Fluor® 488-conjugated goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to cytoplasm. |
| 应用 | ELISA,ICC/IF |
| 推荐剂量 | ELISA: 1:5000-1:10000; ICC-IF: 1:20-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human CNDP1 (rh CNDP1; TMPY-00719; NP_116038.4; Ser27-His507). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | CNDP1, also known as carnosine dipeptidase 1, glutamate carboxypeptidase-like protein 2 (CPGL-2) or carnosinase 1 (CN1), is a member of the M20 metalloprotease family. The CNDP1 gene contains trinucleotide (CTG) repeat length polymorphism in the coding region, which has been demonstrated to be associated with susceptibility to developing diabetic nephropathy, for carnosine protection against the adverse effects of high glucose levels on renal cells. In humans, CNDP1 is secreted from the liver into the serum. In other mammals, including rodents, CNDP1 is expressed exclusively within the kidney and lacks a signal peptide. CNDP1 protein is a secreted homodimeric dipeptidase that specifically hydrolyzes L-carnosine (β-alanyl-L-histidine), and is identified as human carnosinase expressed in the brain. CNDP1 has been associated with diabetic nephropathy in Europeans and European Americans, but not African-Americans. It was identified and confirmed as a risk factor, were cross-sectional and mostly in patients with type 2 diabetes. The polymorphisms of CNDP1 can be excluded as a risk factor for nephropathy in type 1 diabetes. In addition, CNDP1 is also suggested to be implicated in the actions of neuroprotection and neurotransmiting. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human CNDP1 Protein (TMPY-00719) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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