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Latent TGF beta 2 Protein, Mouse, Recombinant (His)

产品编号 TMPY-00413

TGF beta 2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.9 kDa and the accession number is P27090.

Latent TGF beta 2 Protein, Mouse, Recombinant (His)

产品编号 TMPY-00413

TGF beta 2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.9 kDa and the accession number is P27090.

规格	价格	库存
10 μg	¥ 1,350	In stock
100 μg	¥ 6,900	5日内发货
1 mg	¥ 35,600	5日内发货

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产品信息

生物活性	The whole mouse TGF beta 2 protein showed no activity.
产品描述	TGF beta 2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.9 kDa and the accession number is P27090.
种属	Mouse
表达系统	HEK293 Cells
标签	C-His
蛋白编号	P27090
别名	转化生长因子,transforming growth factor β2,transforming growth factor beta 2,TGF-β2,Tgf-β2,Tgf-beta2,TGF-beta 2,Tgfb-2,TGFB2,TGF β2,BB105277
蛋白构建	A DNA sequence encoding the mouse Tgfb2 (NP_033393.2) (Met1-Ser414) was expressed with a polyhistidine tag at the C-terminus. Predicted N terminal: Ser 20
蛋白纯度	> 90 % as determined by SDS-PAGE
分子量	46.9 kDa (predicted)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	TGF beta 2 (Transforming growth factor beta 2), an extracellular glycosylated protein, which belongs to the TGF-beta family. TGF-beta regulates key mechanisms of tumor development, namely immunosuppression, metastasis, angiogenesis, and proliferation. TGF beta 2 suppression is a promising therapeutic approach for malignant tumor therapy. The signaling pathway of TGF beta 2/Smad plays an important role in the pathological process in posterior capsule opacification (PCO) after cataract surgery. Silencing Smad2 and Smad3 efficiently blocked the effect of TGF beta 2 on cell proliferation, migration, and extracellular matrix production. TGF beta 2 activation of MEKK3/ERK1/2/5 signaling modulates Has2 expression and hyaluronan (HA) production leading to the induction of epithelial to mesenchymal transformation (EMT) events. Besides, the upregulation of the TGF beta 2 level is a common pathological feature of Alzheimer's disease (AD) brains and suggests that it may be closely linked to the development of neuronal death related to AD.