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Anti-Phospho-CTNNB1 (Ser33, 37) Antibody (1N602)
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产品编号 TMAH-00889
别名 PRO2286, Phospho-CTNNB1 (S33, 37), p-CTNNB1 (Ser33, 37), p-CTNNB1 (S33, 37), OK/SW-cl.35, NEDSDV, MRD19, EVR7, CTNNB1 (p-Ser33, 37), CTNNB1 (p-S33, 37), CTNNB, beta-catenin, armadillo
Anti-Phospho-CTNNB1 (Ser33, 37) Antibody (1N602) 是一种抗体，靶向 Phospho-CTNNB1 (Ser33, 37)。Anti-Phospho-CTNNB1 (Ser33, 37) Antibody (1N602) 可用于 ELISA, IF。
Anti-Phospho-CTNNB1 (Ser33, 37) Antibody (1N602)
Anti-Phospho-CTNNB1 (Ser33, 37) Antibody (1N602)
还可以产品编号 TMAH-00889 别名 PRO2286, Phospho-CTNNB1 (S33, 37), p-CTNNB1 (Ser33, 37), p-CTNNB1 (S33, 37), OK/SW-cl.35, NEDSDV, MRD19, EVR7, CTNNB1 (p-Ser33, 37), CTNNB1 (p-S33, 37), CTNNB, beta-catenin, armadillo
Anti-Phospho-CTNNB1 (Ser33, 37) Antibody (1N602) 是一种抗体，靶向 Phospho-CTNNB1 (Ser33, 37)。Anti-Phospho-CTNNB1 (Ser33, 37) Antibody (1N602) 可用于 ELISA, IF。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,315 | 5日内发货 | |
| 100 μL | ¥ 2,190 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-Phospho-CTNNB1 (Ser33, 37) Antibody (1N602) is an antibody targeting Phospho-CTNNB1 (Ser33, 37). Anti-Phospho-CTNNB1 (Ser33, 37) Antibody (1N602) can be used in ELISA, IF. |
| 别名 | PRO2286, Phospho-CTNNB1 (S33, 37), p-CTNNB1 (Ser33, 37), p-CTNNB1 (S33, 37), OK/SW-cl.35, NEDSDV, MRD19, EVR7, CTNNB1 (p-Ser33, 37), CTNNB1 (p-S33, 37), CTNNB, beta-catenin, armadillo |
| Ig Type | Rabbit IgG |
| 克隆号 | 1N602 |
| 交叉反应 | Human |
| 验证活性 | Immunofluorescence staining of 293T cells(treated with 50nM Calyculin A for 30min) with TMAH-00889 at 1:100,counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L). |
| 应用 | |
| 推荐剂量 | IF:1:20-1:200. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction. Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cell junction, synapse. Cytoplasm, cytoskeleton, cilium basal body. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle. Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human Phospho-CTNNB1 (S33/S37) |
| 抗原种属 | Human |
| 基因ID | |
| Uniprot ID | |
| 研究领域 | Signal Transduction |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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