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顶部相关产品产品介绍化学信息储存和溶解信息TCMIP相关数据计算器

Tyramine

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Rating icon 很棒

纯度: 99.92%

货号 T3095Cas号 51-67-2

别名 酪胺, Uteramine, Tocosine, p-Tyramine, para-tyramine, 4-hydroxyphenethylamine

Tyramine (Uteramine) 是天然存在于体内或某些食物中的氨基酸。Tyramine 有助于调节血压。

Tyramine
其他形式的 “Tyramine”:
Tyramine hydrochloride (Standard)
Tyramine hydrochloride

Tyramine

一键复制产品信息
Rating icon 很棒

纯度: 99.92%

货号 T3095 别名 酪胺, Uteramine, Tocosine, p-Tyramine, para-tyramine, 4-hydroxyphenethylamineCas号 51-67-2

Tyramine (Uteramine) 是天然存在于体内或某些食物中的氨基酸。Tyramine 有助于调节血压。

规格价格库存数量
500 mg
¥ 331
现货
1 g
¥ 415
现货
1 mL x 10 mM (in DMSO)
¥ 322
现货
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产品介绍

Tyramine AI Summary
Tyramine exhibits a diverse range of bioactivities across multiple assays and targets. It shows high potency in opioid receptor assays, with extremely low IC50 values in both guinea pig ileum and rat brain assays, indicating potential strong opioid agonist activity. The compound also demonstrates high potency in displacing specifically bound [3H]naloxone, suggesting potent opioid receptor binding. In addition to opioid receptors, Tyramine interacts with Dopamine receptors D1 and D2, though with relatively low affinity (Ki values of 390,000 nM and 160,000 nM, respectively), and exhibits low potency in displacing [3H]spiperone from human D2 and D4 receptors. It also shows binding affinity to other receptors such as 5-hydroxytryptamine (serotonin), with a Kd value of 8511.38 nM. Tyramine is evaluated as a substrate for Dopamine beta-hydroxylase (DBH) from bovine adrenals, with a Km value of 2000000 nM and a Kcat value of 85 s-1, and exhibits affinity towards Phenylethanolamine N-Methyltransferase (PNMT) with a Ki value of 294000 nM. Notably, Tyramine has antiplasmodial activity against chloroquine-resistant Plasmodium falciparum, with an IC50 value of 160,000 nM, and exhibits antiviral activity against SARS-CoV-2, inhibiting virus-induced cytotoxicity in VERO-6 cells at an IC50 greater than 20,000 nM. It also inhibits the SARS-CoV-2 3CL-Pro protease with an inhibition percentage of 7.67% at 20µM concentration. Further, Tyramine shows inhibitory effects on enzyme targets such as mushroom tyrosinase, Monoamine Oxidase (MAO-A and MAO-B), and Dopamine beta-monooxygenase. The compound demonstrates weak to moderate binding to Beta adrenergic receptors and significant inhibitory activity in assays for L-tryptophan and TEA uptake. Lastly, Tyramine exhibits agonistic activity at the TAAR1 receptor across human, rat, and mouse models, with varying EC50 values (76 nM, 30 nM, and 280 nM respectively), and an Emax indicating potent receptor activity. It does not induce drug-induced liver injury and shows broad inhibitory effects including antiprotozoal activity against Giardia lamblia and Entamoeba histolytica..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
Tyramine (Uteramine) is an indirect sympathomimetic that occurs naturally in cheese and other foods. Tyramine does not directly activate adrenergic receptors, but it can serve as a substrate for adrenergic uptake systems and MONOAMINE OXIDASE to prolong the actions of adrenergic transmitters. It also provokes transmitter release from adrenergic terminals and may be a neurotransmitter in some invertebrate nervous systems.
靶点活性
TAAR1 (human):34 nM(Ki)
别名酪胺, Uteramine, Tocosine, p-Tyramine, para-tyramine, 4-hydroxyphenethylamine
化学信息
分子量137.18
分子式C8H11NO
CAS No.51-67-2
SmilesNCCc1ccc(O)cc1
密度1.103g/cm3
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
DMSO: 62.5 mg/mL (455.61 mM), Sonication is recommended.
体内实验配方
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (14.58 mM), Sonication is recommended.
请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。
溶液配制表
DMSO
1mg5mg10mg50mg
1 mM7.2897 mL36.4485 mL72.8969 mL364.4846 mL
5 mM1.4579 mL7.2897 mL14.5794 mL72.8969 mL
10 mM0.7290 mL3.6448 mL7.2897 mL36.4485 mL
20 mM0.3645 mL1.8224 mL3.6448 mL18.2242 mL
50 mM0.1458 mL0.7290 mL1.4579 mL7.2897 mL
100 mM0.0729 mL0.3645 mL0.7290 mL3.6448 mL

TCMIP相关数据

中药材来源及性味归经
中药材名称中药材拉丁名性味归经
暗绿龙舌兰Agave americanaL.温苦, 酸
白屈菜Chelidonium majus L.凉苦肺, 胃
所属中成药
中成药名称处方组成中成药类型
胃刻宁片白屈菜,黄柏,海螵蛸,白矾(煅),薄荷脑理气药
小儿清热灵白屈菜,寒水石,黄芩,重楼,柴胡,天竺黄,紫荆皮,射干,板蓝根,牛黄,菊花,冰片,蝉蜕,珍珠,黄连,麝香清热药
胃痛平胶囊白屈菜清热药
复方白头翁胶囊盐酸小檗碱,白屈菜,白头翁,秦皮清热药
小儿消咳片白屈菜,百部,天冬,南沙参,白前,侧柏叶,木蝴蝶清热药
新型狗皮膏川乌,羌活,高良姜,肉桂,当归,防己,麻黄,红花,洋金花,白屈菜,花椒,蟾酥,白花菜子,透骨草,没药,乳香,薄荷脑,冰片,樟脑,水杨酸甲酯,八角茴香油,盐酸苯海拉明和血药
元秦止痛注射液延胡索,制川乌,秦艽,粉防己,白屈菜祛瘀药
复方白头翁片白头翁,盐酸小檗碱,白屈菜,秦皮清热药
胃刻宁胶囊白屈菜,黄柏,海螵蛸,白矾(煅),薄荷脑理气药
天蟾胶囊夏天无,制川乌,蟾酥,祖司麻,白屈菜,秦艽,白芷,川芎,白芍,甘草祛瘀药
小儿白贝止咳糖浆白屈菜,瓜蒌,法半夏,平贝母化痰药
痛安注射液青风藤,白屈菜,汉桃叶祛湿药
胃痛平糖浆白屈菜温里药

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
TargetMol | Animal experiments 比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments 一共给药动物10只，您使用的配方为5%TargetMol | reagent DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent （ 母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法: 取 50μLDMSOTargetMol | reagent 母液，添加 300 μLPEG300TargetMol | reagent 混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline/PBS/ddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ， 玉米油 等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

TyramineMAOsEndogenousMetaboliteEndogenous Metabolite
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