S100A4 Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 11.7 kDa and the accession number is P07091.
生物活性 | Testing in progress |
产品描述 | S100A4 Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 11.7 kDa and the accession number is P07091. |
种属 | Mouse |
表达系统 | HEK293 Cells |
标签 | Tag Free |
蛋白编号 | P07091 |
别名 | PeL98, 18A2, 42a, Capl, pk9a, FSp1, metastasin, S100 calcium binding protein A4, Mts1 |
蛋白构建 | The Mouse S100A4 (P07091)(Ala2-Lys101) was expressed and purified with two additional amino acids (Gly & Pro) at the N-terminus. |
蛋白纯度 | > 85 % as determined by SDS-PAGE |
分子量 | 11.7 kDa (predicted) |
内毒素 | < 1.0 EU/μg of the protein as determined by the LAL method. |
缓冲液 | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
复溶方法 | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
存储 |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
运输方式 |
In general, Lyophilized powders are shipping with blue ice. |
研究背景 | S100A4, also known as metastasis-associated protein Mtsl, belongs to the family of small calcium-binding S100 proteins containing two EF-hand calcium-binding motifs. In humans at least 20 S100 family members that are distributed tissue specifically have been identified, and are involved in a number of cellular processes as transducers of calcium signal. S100A4 is a symmetric homodimer, and undergoes a relatively large conformational change upon the typical EF-hand binding calcium, which is necessary for S100A4 to interact with its protein targets and generate biological effects. It can bind the already known targets p53, F-actin, liprin β, myosin heavy chain II, and prevent their phosphorylation and multimerization. It has been demonstrated that S100A4 is directly involved in tumor metastasis including cell motility, invasion, apoptosis, angiogenesis and differentiation, and appears to be a metastasis factor and a molecular marker for clinical prognosis. Multiple alternatively spliced variants encoding the same protein have been identified. |
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S100A4 Protein, Mouse, Recombinant PeL98 18A2 42a Capl pk9a FSp1 metastasin S100 calcium binding protein A4 Mts1 recombinant recombinant-proteins proteins protein