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2-Iodoacetamide

Name: 2-Iodoacetamide
Brand: TargetMol
SKU: T8897
Price: 127 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.95%

货号 T8897Cas号 144-48-9

别名 碘乙酰胺, Iodoacetamide

2-Iodoacetamide (Iodoacetamide) 是常用的烷基化剂之一，能够在蛋白质组学样品制备过程中，将半胱氨酸烷基化。

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2-Iodoacetamide

一键复制产品信息

很棒

纯度: 99.95%

货号 T8897 别名 碘乙酰胺, IodoacetamideCas号 144-48-9

2-Iodoacetamide (Iodoacetamide) 是常用的烷基化剂之一，能够在蛋白质组学样品制备过程中，将半胱氨酸烷基化。

规格	价格	库存
100 mg	¥ 127	现货
500 mg	¥ 279	现货
1 g	¥ 396	现货
5 g	¥ 662	现货
10 g	¥ 993	现货
1 mL x 10 mM (in DMSO)	¥ 298	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.95%

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COA HNMR LCMS 产品操作手册

产品介绍

2-Iodoacetamide AI Summary

2-Iodoacetamide exhibits a broad spectrum of bioactivities and notable inhibitory capabilities. It is effective in inactivating rat muscle adenylate kinase and inhibiting adenylate kinase II, influencing enzyme inactivation half-time and rate. The compound also shows potent inhibition of horse liver alcohol dehydrogenase with a Ki value of 1905460.72 nM, and exhibits a logP value of 0.15. Furthermore, 2-Iodoacetamide significantly inhibits Aryl Hydrocarbon Activation (AHAT) by 99.0% at a 1 mM concentration using compound 8 and compound 10 as substrates. In addition, it inhibits thymidylate synthetase with a rate constant (k2) of 7.0 M^-1 at pH 7 and 24°C, and demonstrates potent inhibition of HIV YU2 gp120 binding to CD4 with an IC50 value of 33.3 nM. The compound also activates TRPA1 with an EC50 value of 357000.0 nM. In enzyme assays, 2-Iodoacetamide shows inhibitory activity against HSD17B4, RECQ1, JMJD2E, Tyrosyl-DNA Phosphodiesterase (TDP1), Cytochrome P450 2C19, Aldehyde Dehydrogenase 1 (ALDH1A1), and others, indicating extensive modulation across various biological pathways. It also displays significant activity in assays involving Lamin A Splicing, Histone Lysine Methyltransferases such as G9a, and the Regulator of G Protein Signaling (RGS) 4, among others. Moreover, 2-Iodoacetamide inhibits Pantoea ananatis lycopene cyclase, leaving 87.0% residual enzyme activity at 0.5 mM concentration and exhibits cysteine reactivity with a determined second-order rate constant of 25.0 /M/s assessed by 1H NMR. The compound also binds to human plasma coagulation factor XIIIa with a rate constant of 0.8 x 10^4/M/s and demonstrates a significant rate constant ratio to Glutathione. Overall, 2-Iodoacetamide’s diverse bioactivities and broad inhibitory profile underscore its potential as a multi-target therapeutic agent..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Iodoacetamide, an alkylating agent, is commonly utilized for cysteine alkylation in proteomics sample preparation.
别名	碘乙酰胺, Iodoacetamide

化学信息

分子量	184.96
分子式	C₂H₄INO
CAS No.	144-48-9
Smiles	NC(=O)CI
密度	2.1103 g/cm3 (Estimated)
颜色	Yellow
物理性状	Solid

储存&溶解度

存储

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (270.33 mM), Sonication is recommended.

H2O: 50 mg/mL (270.33 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.81 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	5.4066 mL	27.0329 mL	54.0657 mL	270.3287 mL
5 mM	1.0813 mL	5.4066 mL	10.8131 mL	54.0657 mL
10 mM	0.5407 mL	2.7033 mL	5.4066 mL	27.0329 mL
20 mM	0.2703 mL	1.3516 mL	2.7033 mL	13.5164 mL
50 mM	0.1081 mL	0.5407 mL	1.0813 mL	5.4066 mL
100 mM	0.0541 mL	0.2703 mL	0.5407 mL	2.7033 mL