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Anti-CBFB Antibody (1I567)
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产品编号 TMAC-00628
别名 PEBP2B, core-binding factor, β subunit, core-binding factor, beta subunit
Anti-CBFB Antibody (1I567) 是一种 Rabbit 抗体，靶向 CBFB。Anti-CBFB Antibody (1I567) 可用于 WB,IHC,FCM。
Anti-CBFB Antibody (1I567)
Anti-CBFB Antibody (1I567)
还可以产品编号 TMAC-00628 别名 PEBP2B, core-binding factor, β subunit, core-binding factor, beta subunit
Anti-CBFB Antibody (1I567) 是一种 Rabbit 抗体，靶向 CBFB。Anti-CBFB Antibody (1I567) 可用于 WB,IHC,FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,495 | 5日内发货 | |
| 100 μL | ¥ 2,490 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
化学信息
| 产品描述 | Anti-CBFB Antibody (1I567) is a Rabbit antibody targeting CBFB. Anti-CBFB Antibody (1I567) can be used in WB,IHC,FCM. |
| 别名 | PEBP2B, core-binding factor, β subunit, core-binding factor, beta subunit |
| Ig Type | IgG |
| 交叉反应 | Human,Rat |
| 验证活性 | 1. Immunohistochemical analysis of paraffin-embedded rat kidney tissue using anti-CBFb antibody. Counter stained with hematoxylin. 2. Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-CBFb antibody. Counter stained with hematoxylin. 3. Flow cytometric analysis of SiHa cells with CBFb antibody at 1/100 dilution (purple) compared with an unlabelled control (cells without incubation with primary antibody; yellow). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the secondary antibody. |
| 应用 | |
| 推荐剂量 | IHC: 1:50-200; FCM: 1:50-100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | The transcription factor Polyomavirus enhancer binding protein 2 (PEBP2), also designated Osf2 (Osteoblast-specific transcription factor), CBFA1 (Core Binding Factor) and AML3 (Acute myeloid leukemia), is composed of two subunits, a and b, which are essential for the regulation of hematopoiesis and osteogenesis. The PEBP2a subunits, PEBP2aA, PEBP2aB and PEBP2aC, are encoded by three RUNX genes, all of which contain a 128-amino acid region homologous to the highly conserved Drosophila segmentation gene, Runt. This region is involved in DNA binding and heterodimerization with the regulatory b subunit, which facilitates DNA binding of the a subunit. Both subunits are required for in vivo function; the disruption of either gene results in a lack of definitive hematopoiesis followed by embryo death in utero due to hemorrhage in the central nervous system. The gene encoding PEBP2b is the target of chromosomal inversion 16 (p13;q22) with the smooth muscle myosin heavy chain, producing a chimeric gene, PEBP2b/CBFB-SMMHC, that is associated with human acute myeloid leukemia. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: human CBFb aa 1-200 |
| 抗原种属 | human |
| Uniprot ID |
| 分子量 | Theoretical: 22 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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