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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Beta Klotho Polyclonal Antibody

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货号 TMAB-00211

别名 Klotho beta-like protein, KLB, BKL, Beta-klotho, BetaKlotho

Anti-Beta Klotho Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Beta Klotho。Anti-Beta Klotho Polyclonal Antibody 可用于 ELISA,ICC/IF,IF,IHC-Fr,IHC-P,WB。

Anti-Beta Klotho Polyclonal Antibody

Anti-Beta Klotho Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-00211 别名 Klotho beta-like protein, KLB, BKL, Beta-klotho, BetaKlotho

Anti-Beta Klotho Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Beta Klotho。Anti-Beta Klotho Polyclonal Antibody 可用于 ELISA,ICC/IF,IF,IHC-Fr,IHC-P,WB。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-Beta Klotho Polyclonal Antibody is a Rabbit antibody targeting Beta Klotho. Anti-Beta Klotho Polyclonal Antibody can be used in ELISA,ICC/IF,IF,IHC-Fr,IHC-P,WB.
别名Klotho beta-like protein, KLB, BKL, Beta-klotho, BetaKlotho
Ig Type
IgG
反应种属
(predicted:Human,Mouse,Rat,Sheep)
应用ELISAICC/IFIFIHC-FrIHC-PWB
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:100-500; IF: 1:100-500; ELISA: 1:5000-10000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell membrane.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1 mg/mL
研究背景BetaKlotho is a 1044 amino acid single-pass type III membrane protein that plays a key role in bile acid and cholesterol metabolism by suppressing transcription of CYP7A1 (cholesterol 7-alpha-hydroxylase), the rate-limiting enzyme in bile acid synthesis. Homozygous negative betaKlotho mice showed dramatically elevated bile acid synthesis and secretion, as well as a strong upregulation of CYP7A1 and CYP8B1 and resistance to gallstone formation. FGF19 and FGF21 require direct interaction with betaKlotho for activation, intracellular signaling and gene expression modulation. Both Klotho and betaKlotho consist of two internal repeats similar to family 1 glycosidases. BetaKlotho contains two glycosyl hydrolase 1 regions, however since these regions lack essential glutamic acid residues at specific and crucial locations, the domains appear to be inactive.
抗原信息
免疫原
KLH conjugated synthetic peptide: human KLB
抗原种属
Human
基因名称
KLB
基因ID
152831
蛋白名称
beta-klotho
Uniprot ID
Q86Z14
研究领域
Cholesterol Metabolism,Other factors,Energy Metabolism,Cholesterol Metabolism,Cancer,FGF,Energy Metabolism,Lipid metabolism
功能
Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21.
化学信息
分子量Theoretical: 125 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | store at -20°C

计算器

  • 稀释 计算器

关键词

BetaKlothoProtein,Human,Recombinant(aa53983,His)
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