Name: LEAP-2 acetate
Brand: TargetMol
SKU: T81944L
Rating: 4.5 (1 reviews)

生物活性

产品描述	LEAP-2 acetate (Human liver expressed antimicrobial peptide-2) is an endogenous antagonist of the ghrelin receptor GHS-R1a with an IC50 of 6.0 nM, suppressing the orexigenic effects of ghrelin, attenuating ghrelin-induced growth hormone release, reducing basal food intake. LEAP-2 acetateexhibit direct antimicrobial activity against model microorganisms, thereby serving as a multifunctional peptide for mechanistic studies of obesity, metabolism, and infection biology.
靶点活性	GHSR1a:1-3 nM (Ki)
体内活性	在代谢小鼠模型中，LEAP-2 acetate 作为一种饱腹感信号发挥作用。其血浆水平与 Ghrelin 呈负相关；禁食期间水平下降，而在重新进食后上升。给予 LEAP-2 acetate 可抑制食欲，并通过阻断胰岛素分泌的减少来预防由 Ghrelin 诱导的高血糖。在饮食诱导的肥胖小鼠中，长期给予或过表达 LEAP-2 acetate 会导致摄食量减少和体重减轻 [1]。
别名	LEAP-2 醋酸盐, LEAP-2 acetate （1683582-94-6 Free base）, Human liver expressed antimicrobial peptide-2 acetate

化学信息

Sequence	Met-Thr-Pro-Phe-Trp-Arg-Gly-Val-Ser-Leu-Arg-Pro-Ile-Gly-Ala-Ser-Cys-Arg-Asp-Asp-Ser-Glu-Cys-Ile-Thr-Arg-Leu-Cys-Arg-Lys-Arg-Arg-Cys-Ser-Leu-Ser-Val-Ala-Gln-Glu (Disulfide bridge:Cys17-Cys28;Cys23-Cys33)
Sequence Short	MTPFWRGVSLRPIGASCRDDSECITRLCRKRRCSLSVAQE (Disulfide bridge:Cys17-Cys28;Cys23-Cys33)

储存&溶解度

存储

LEAP-2 acetate