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Anti-PRKCQ Antibody (3M200)
还可以产品编号 TMAH-01004
别名 Protein kinase C theta type, PRKCT, nPKC-theta, EC 2.7.11.13
Anti-PRKCQ Antibody (3M200) 是一种抗体，靶向 PRKCQ。Anti-PRKCQ Antibody (3M200) 可用于 ELISA, WB。
Anti-PRKCQ Antibody (3M200)
Anti-PRKCQ Antibody (3M200)
还可以产品编号 TMAH-01004 别名 Protein kinase C theta type, PRKCT, nPKC-theta, EC 2.7.11.13
Anti-PRKCQ Antibody (3M200) 是一种抗体，靶向 PRKCQ。Anti-PRKCQ Antibody (3M200) 可用于 ELISA, WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,300 | 5日内发货 | |
| 100 μL | ¥ 2,180 | 5日内发货 |
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-PRKCQ Antibody (3M200) is an antibody targeting PRKCQ. Anti-PRKCQ Antibody (3M200) can be used in ELISA, WB. |
| 别名 | Protein kinase C theta type, PRKCT, nPKC-theta, EC 2.7.11.13 |
| Ig Type | Rabbit IgG |
| 克隆号 | 3M200 |
| 交叉反应 | Human, Mouse |
| 验证活性 | Western Blot -Positive WB detected in: 293T whole cell lysate, K562 whole cell lysate, THP-1 whole cell lysate, Mouse Brain whole cell lysate -All lanes: PKC antibody at 1:1000 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 82, 75, 68 kDa -Observed band size: 82, 55 kDa |
| 应用 | ELISA, WB |
| 推荐剂量 | WB:1:500-1:5000. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Cytoplasm. Cell membrane; Peripheral membrane protein. Note=In resting T-cells, mostly localized in cytoplasm. In response to TCR stimulation, associates with lipid rafts and then localizes in the immunological synapse. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in 'outside-in' signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively regulates its ability to phosphorylate PKB/AKT1. Phosphorylates CCDC88A/GIV and inhibits its guanine nucleotide exchange factor activity. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human PKC theta |
| 抗原种属 | Human |
| 基因ID | 5588 |
| Uniprot ID | |
| 研究领域 | Signal transduction |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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