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Anti-IFNAR2 Antibody (6X418)
还可以产品编号 TMAY-00684
Anti-IFNAR2 Antibody (6X418) 是一种 Mouse 抗体，靶向 IFNAR2。Anti-IFNAR2 Antibody (6X418) 可用于 WB。
Anti-IFNAR2 Antibody (6X418)
Anti-IFNAR2 Antibody (6X418)
还可以产品编号 TMAY-00684
Anti-IFNAR2 Antibody (6X418) 是一种 Mouse 抗体，靶向 IFNAR2。Anti-IFNAR2 Antibody (6X418) 可用于 WB。
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| 产品描述 | Anti-IFNAR2 Antibody (6X418) is a Mouse antibody targeting IFNAR2. Anti-IFNAR2 Antibody (6X418) can be used in WB. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 6X418 |
| 交叉反应 | Human |
| 验证活性 | Anti-IFNaR2 mouse monoclonal antibody at 1:500 dilution. -Lane A: HepG2 Whole Cell Lysate. -Lane B: Jurkat Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Mouse IgG H&L (Dylight800) at 1/15000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:57 kDa. -Observed band size:37 kDa |
| 应用 | WB |
| 推荐剂量 | WB: 1:500-1:1000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IFNAR2 (rh IFNAR2; TMPY-01642; NP_997468.1; Met1-Lys243). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Interferon-alpha/beta receptor beta chain (IFNAR2) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Initial cell-surface IFNAR2 expression at diagnosis assessed by flow cytometry was widely distributed but showed overall significantly higher expression in CML patients when compared with normal controls. In 15 fresh patients who subsequently received IFNα therapy, IFNAR2 expression at diagnosis was significantly higher in cytogenetic good responders than in poor responders. Down-regulation of IFNAR2 expression during IFNα therapy was observed only in good responders but not in poor responders. The encoded protein also functions as an antiviral factor. IFNAR2 may associate with IFNAR1 to form the type I interferon receptor. This protein serves as a receptor for interferons alpha and beta. IFNAR2 is also involved in IFN-mediated STAT1, STAT2, and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. Following binding of IFNα2, IFNAR2 is internalized, but, instead of being routed towards degradation as it is when complexed to IFNβ, it recycles back to the cell surface. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human IFNAR2 protein (TMPY-01642) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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