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TGFBR3 Protein, Human, Recombinant (His)

TGFBR3 Protein, Human, Recombinant (His)

产品编号 TMPY-03649
别名: βglycan, betaglycan, transforming growth factor, beta receptor III, transforming growth factor, β receptor III, BGCAN

TGFBR3 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 42.2 kDa and the accession number is Q03167-1.

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TGFBR3 Protein, Human, Recombinant (His)
规格 价格/CNY 货期 数量
100 μg ¥ 3,820 5日内发货
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产品目录号及名称: TGFBR3 Protein, Human, Recombinant (His) (TMPY-03649)
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生物活性 Testing in progress
产品描述 TGFBR3 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 42.2 kDa and the accession number is Q03167-1.
种属 Human
表达系统 Baculovirus Insect Cells
标签 C-His
蛋白编号 Q03167-1
别名 βglycan, betaglycan, transforming growth factor, beta receptor III, transforming growth factor, β receptor III, BGCAN
蛋白构建 Human TGFBR3 (Q03167-1) (Met 1-Gly781)
蛋白纯度 > 95 % as determined by SDS-PAGE
分子量 42.2 kDa (predicted)
内毒素 < 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris, 500 mM NaCl, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 Betaglycan also known as transforming growth factor beta receptor III (TGFBR3), is a cell-surface chondroitin sulfate / heparan sulfate proteoglycan. TGFBR3 is a transforming growth factor (TGF)-beta type III receptor. This receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. TGFBR3 is the TGF-β component most commonly downregulated among localized human prostate cancer studies. TGFBR3 knockdown led to focus formation and enhanced expression of CD133, a marker found on prostate cancer stem cells. TGFBR3 is an accessory receptor that binds to and modulates the activities of both transforming growth factor-beta (TGFβ) and inhibin, two members of the TGFβ superfamily of growth factors that regulate many aspects of reproductive biology. TGFBR3 is known to be expressed in adult testis and ovary, but little is known about this receptor during gonadogenesis.

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Keywords

TGFBR3 Protein, Human, Recombinant (His) βglycan transforming growth factor, b receptor III betaglycan transforming growth factor, beta receptor III transforming growth factor, β receptor III BGCAN recombinant recombinant-proteins proteins protein

 

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