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IFNAR1 Protein, Mouse, Recombinant (His)

产品编号 TMPY-01489

别名: Ifrc, Ifar, CD118, interferon (α, β and ω) receptor 1, interferon (α, β and Ω) receptor 1, Infar, interferon (alpha, beta and omega) receptor 1, Ifnar

IFNAR1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47 kDa and the accession number is P33896.

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IFNAR1 Protein, Mouse, Recombinant (His)

规格	价格/CNY		货期	数量
100 μg	￥ 3,820		5日内发货

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参考文献

生物活性	Measured by its ability to inhibit mIFNB1-mediated protection of L929 mouse fibroblast cells infected with vesicular stomatitis virus (VSV) to viral lysis. The ED50 for this effect is typically 0.2-1μg/mL.
产品描述	IFNAR1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47 kDa and the accession number is P33896.

种属	Mouse
表达系统	HEK293 Cells
标签	C-His
蛋白编号	P33896
别名	Ifrc, Ifar, CD118, interferon (α, β and ω) receptor 1, interferon (α, β and Ω) receptor 1, Infar, interferon (alpha, beta and omega) receptor 1, Ifnar
蛋白构建	The extracellular domain of Mouse IFNAR1 (NP_034638.2) extracellular domain (Met 1-Thr 429) was expressed, with a polyhistidine tag at the C-terminus.
蛋白纯度	> 96 % as determined by SDS-PAGE
分子量	47 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1, in which Tyr466 is changed to phenylalanine, can act in a dominant-negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.

参考文献

1. Yan H,et al.(1996) Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein. EMBO J. 15(5): 1064-74. 2. Richter MF,et al.(1998) Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1. J Biol Chem. 273(38): 24723-9. 3. Abramovich C,et al.(1997) A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor. EMBO J. 16(2): 260-6.

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Keywords

IFNAR1 Protein, Mouse, Recombinant (His) Ifrc CD 118 Ifar CD118 interferon (α, β and ω) receptor 1 CD-118 interferon (α, β and Ω) receptor 1 Infar interferon (alpha, beta and omega) receptor 1 interferon (a, b and w) receptor 1 Ifnar recombinant recombinant-proteins proteins protein

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