购物车
- 全部删除
您的购物车当前为空
Anti-BACE1 Antibody-PE (8D358)
还可以产品编号 TMAY-00206P
Anti-BACE1 Antibody-PE (8D358) 是一种 PE-conjugated Rabbit 抗体，靶向 BACE1。Anti-BACE1 Antibody-PE (8D358) 可用于 FCM。
Anti-BACE1 Antibody-PE (8D358)
Anti-BACE1 Antibody-PE (8D358)
还可以产品编号 TMAY-00206P
Anti-BACE1 Antibody-PE (8D358) 是一种 PE-conjugated Rabbit 抗体，靶向 BACE1。Anti-BACE1 Antibody-PE (8D358) 可用于 FCM。
产品信息正在更新中，如果您想购买，请点击大包装&定制按钮.
大包装 & 定制
联系我们获取更多批次信息
资源下载
产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-BACE1 Antibody-PE (8D358) is a PE-conjugated Rabbit antibody targeting BACE1. Anti-BACE1 Antibody-PE (8D358) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 8D358 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human BACE1 expression in Jurkat cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), and then stained with PE Rabbit anti-BACE1. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | 5 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human BACE1 / ASP2 (rh BACE1 / ASP2; TMPY-00752; NP_036236.1; Met 1-Thr 457) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| 研究背景 | Beta-site APP-cleaving enzyme 1 (BACE1) is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. In the brain, This protein is expressed highly in the substantia nigra, locus coruleus and medulla oblongata. Strong BACE1 expression has also been described in pancreatic tissue. BACE1 has a pivotal role in the pathogenesis of Alzheimer's disease. In Alzheimer's disease patients, BACE1 levels were elevated although mRNA levels were not changed. It has been found that BACE1 gene expression is controlled by a TATA-less promoter. The translational repression as a new mechanism controlling its expression. And the low concentrations of Ca(2+) (microM range) significantly increased the proteolytic activity of BACE1. Furthermore, BACE1 protein is ubiquitinated, and the degradation of BACE1 proteins and amyloid precursor protein processing are regulated by the ubiquitin-proteasome pathway. It has also been identified as the rate limiting enzyme for amyloid-beta-peptide (Abeta) production. |
| 偶联 | PE |
| 其他可选修饰符 | Unconjugated/FITC |
| 可提供抗体种类 | 3 |
| 免疫原 | Recombinant Human BACE1 / ASP2 protein (TMPY-00752) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| 运输方式 | Shipping with blue ice. |
SCI 文献
计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
评论列表
预览
Related Tags: buy Anti-BACE1 Antibody-PE (8D358) | purchase Anti-BACE1 Antibody-PE (8D358) | Anti-BACE1 Antibody-PE (8D358) cost | order Anti-BACE1 Antibody-PE (8D358)
嗨！有任何问题？点我咨询
评论内容