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FGFR1 Protein, Human, Recombinant (beta (IIIb), His)

产品编号 TMPY-06034

别名: FLG, CD331, N-SAM, HBGFR, HRTFDS, BFGFR, OGD, KAL2, fibroblast growth factor receptor 1, HH2, FGFR-1, bFGF-R-1, FGFBR, FLT-2, CEK, FLT2

FGFR1 Protein, Human, Recombinant (beta (IIIb), His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 30.8 kDa and the accession number is H9FRD4.

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FGFR1 Protein, Human, Recombinant (beta (IIIb), His)

规格	价格/CNY		货期	数量
200 μg	￥ 5,770		现货

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生物活性	Testing in progress
产品描述	FGFR1 Protein, Human, Recombinant (beta (IIIb), His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 30.8 kDa and the accession number is H9FRD4.

种属	Human
表达系统	HEK293 Cells
标签	C-His
蛋白编号	H9FRD4
别名	FLG, CD331, N-SAM, HBGFR, HRTFDS, BFGFR, OGD, KAL2, fibroblast growth factor receptor 1, HH2, FGFR-1, bFGF-R-1, FGFBR, FLT-2, CEK, FLT2
蛋白构建	The Human FGFR1 beta (IIIb) (NP_075594.1) (Met1-Lys221 and Ala270-Glu285 linked by the FGFR1 IIIb Ig domain (AAB19502.1) (His1-Pro47)) was expressed with a polyhistidine tag at the C-terminus.
蛋白纯度	> 90 % as determined by SDS-PAGE.
分子量	30.8 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	FGFR1, also known as CD331, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. Fibroblast growth factors (FGFs) (FGF1 - 10 and 16 - 23) are mitogenic signaling molecules that have roles in angiogenesis, wound healing, cell migration, neural outgrowth and embryonic development. FGFs bind heparan sulfate glycosaminoglycans, which facilitates dimerization (activation) of FGF receptors. FGFR1 is a full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR1 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. CD331 can be detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells. Defects in FGFR1 are a cause of Pfeiffer syndrome ，idiopathic hypogonadotropic hypogonadism， Kallmann syndrome type 2, osteoglophonic dysplasia and trigonocephaly non-syndromic.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

参考文献

1. Schlessinger J,et al.(2000) Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization. Mol Cell. 6(3):743-50. 2. Dodé C,et al.(2007) Novel FGFR1 sequence variants in Kallmann syndrome, and genetic evidence that the FGFR1c isoform is required in olfactory bulb and palate morphogenesis. Hum Mutat. 28(1): 97-8. 3. Kim HG,et al.(2005) Hypogonadotropic hypogonadism and cleft lip and palate caused by a balanced translocation producing haploinsufficiency for FGFR1. J Med Genet. 42(8):666-72.

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Keywords

FGFR1 Protein, Human, Recombinant (beta (IIIb), His) FLG CD331 FLT 2 KAL 2 N-SAM HBGFR CD-331 KAL-2 HRTFDS BFGFR OGD HH-2 KAL2 fibroblast growth factor receptor 1 HH2 FGFR-1 bFGF-R-1 FGFBR FLT-2 CD 331 FGFR 1 CEK HH 2 FGFR1 FLT2 recombinant recombinant-proteins proteins protein

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