Name: Peptide 78
Brand: TargetMol
SKU: TP2347
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

100 mg

待询

500 mg

待询

生物活性

产品描述	Peptide 78, also known as epithelial neutrophil-activating peptide (ENA-78), is a CXC chemokine that acts as a potent chemoattractant and activator of neutrophils. Quantified data show that interleukin-1beta stimulation of relevant stromal cells can induce a 23-fold increase in ENA-78 secretion, while lipopolysaccharide stimulation of macrophages results in an 8-fold increase. Research applications include investigating its elevated concentrations in peritoneal fluid and its expression by ectopic epithelial and stromal cells, making it a valuable tool for studying inflammatory cell recruitment in disease models.
体内活性	采用LPS诱导的急性呼吸窘迫综合征BALB/c小鼠模型（LPS剂量20 mg/kg）。通过腹腔注射给予PDTC（吡咯烷二硫代氨基甲酸酯）干预。模型组小鼠肺组织中Peptide 78（ENA-78）表达显著升高，与肺部中性粒细胞浸润程度呈正相关。PDTC处理后，肺组织ENA-78水平下降，同时支气管肺泡灌洗液中性粒细胞计数减少，表明抑制ENA-78可缓解中性粒细胞驱动的肺部炎症反应。
别名	Thr-met-arg-lys-pro-arg-ser-gly-asn-pro-asp-val-ala-asn, Peptide-78, Peptide78

化学信息

分子量	1542.74
分子式	C₆₂H₁₀₇N₂₃O₂₁S
CAS No.	132116-62-2
Smiles	CSCC[C@H](NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(O)=O
密度	no data available
Sequence	H-Thr-Met-Arg-Lys-Pro-Arg-Ser-Gly-Asn-Pro-Asp-Val-Ala-Asn-OH
Sequence Short	TMRKPRSGNPDVAN

储存&溶解度

存储	Keep away from moisture, Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

Peptide 78