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Anti-BACE1 Antibody (3R945)
还可以产品编号 TMAY-00204
别名 β-site APP-cleaving enzyme 1, HSPC104, beta-site APP-cleaving enzyme 1, BACE, ASP2
Anti-BACE1 Antibody (3R945) 是一种 Mouse 抗体，靶向 BACE1。Anti-BACE1 Antibody (3R945) 可用于 ELISA。
Anti-BACE1 Antibody (3R945)
Anti-BACE1 Antibody (3R945)
还可以产品编号 TMAY-00204 别名 β-site APP-cleaving enzyme 1, HSPC104, beta-site APP-cleaving enzyme 1, BACE, ASP2
Anti-BACE1 Antibody (3R945) 是一种 Mouse 抗体，靶向 BACE1。Anti-BACE1 Antibody (3R945) 可用于 ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 1,694 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-BACE1 Antibody (3R945) is a Mouse antibody targeting BACE1. Anti-BACE1 Antibody (3R945) can be used in ELISA. |
| 别名 | β-site APP-cleaving enzyme 1, HSPC104, beta-site APP-cleaving enzyme 1, BACE, ASP2 |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 3R945 |
| 交叉反应 | Human |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:1000-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human BACE1 extracellular domain (rhBACE1; TMPY-00752; Met 1-Thr 457; NP_036236.1). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Beta-site APP-cleaving enzyme 1 (BACE1) is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. In the brain, This protein is expressed highly in the substantia nigra, locus coruleus and medulla oblongata. Strong BACE1 expression has also been described in pancreatic tissue. BACE1 has a pivotal role in the pathogenesis of Alzheimer's disease. In Alzheimer's disease patients, BACE1 levels were elevated although mRNA levels were not changed. It has been found that BACE1 gene expression is controlled by a TATA-less promoter. The translational repression as a new mechanism controlling its expression. And the low concentrations of Ca(2+) (microM range) significantly increased the proteolytic activity of BACE1. Furthermore, BACE1 protein is ubiquitinated, and the degradation of BACE1 proteins and amyloid precursor protein processing are regulated by the ubiquitin-proteasome pathway. It has also been identified as the rate limiting enzyme for amyloid-beta-peptide (Abeta) production. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human BACE1 protein (TMPY-00752) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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