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顶部生物活性储存和溶解信息计算器

Anti-Phospho-GSK3 beta (Ser9) Antibody (7D812)

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Anti-Phospho-GSK3 beta (Ser9) Antibody (7D812)
产品编号 TMAY-01513
别名 Phospho-GSK3 beta (S9), p-GSK3 beta (Ser9), p-GSK3 beta (S9), GSK3 beta (p-Ser9), GSK3 beta (p-S9)

Anti-Phospho-GSK3 beta (Ser9) Antibody (7D812) 是一种 Rabbit 抗体，靶向 Phospho-GSK3 beta (Ser9)。Anti-Phospho-GSK3 beta (Ser9) Antibody (7D812) 可用于 WB。

Anti-Phospho-GSK3 beta (Ser9) Antibody (7D812)
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Anti-Phospho-GSK3 beta (Ser9) Antibody (7D812)

Rating icon 还可以
Anti-Phospho-GSK3 beta (Ser9) Antibody (7D812)
产品编号 TMAY-01513 别名 Phospho-GSK3 beta (S9), p-GSK3 beta (Ser9), p-GSK3 beta (S9), GSK3 beta (p-Ser9), GSK3 beta (p-S9)

Anti-Phospho-GSK3 beta (Ser9) Antibody (7D812) 是一种 Rabbit 抗体，靶向 Phospho-GSK3 beta (Ser9)。Anti-Phospho-GSK3 beta (Ser9) Antibody (7D812) 可用于 WB。

规格价格库存数量
20 μL
¥ 694
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100 μL
¥ 1,989
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-GSK3 beta (Ser9) Antibody (7D812) is a Rabbit antibody targeting Phospho-GSK3 beta (Ser9). Anti-Phospho-GSK3 beta (Ser9) Antibody (7D812) can be used in WB.
别名Phospho-GSK3 beta (S9), p-GSK3 beta (Ser9), p-GSK3 beta (S9), GSK3 beta (p-Ser9), GSK3 beta (p-S9)
Ig Type
Rabbit IgG
克隆号
7D812
交叉反应
Human;
Species predicted to react based on 100% sequence homology: mouse, rat
验证活性
1. Western blot analysis of extracts from serum-starved Hela treated with calyculin A (100nM, 30 min), using Phospho-GSK3 beta (Ser9) Antibody, Rabbit MAb at 1:1000, 1:10000, 1:200000 dilution. (Validation Experiment)
2. Western blot analysis of extracts from serum-starved Hela, untreated (-) or treated with Calyculin A (100 nM, 30 min; +), using Phospho-GSK3 beta (Ser9) rabbit monoclonal Antibody at 1:1000 dilution.
应用
WB
推荐剂量
WB: 1:1000-1:5000
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with a synthetic peptide corresponding to residues around Ser9 of Human Phospho-GSK3 beta.
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景GSK3B is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It Contains 1 protein kinase domain, and is expressed in the testis, thymus, prostate, and ovary and weakly expressed in the lung, brain, and kidney. GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in the GSK3B gene have been implicated in modifying the risk of Parkinson's disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer's disease. GSK3B participates in the Wnt signaling pathway. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB, and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. GSK3B also plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. GSK3B phosphorylates MACF1 and this phosphorylation inhibits the binding of MACF1 to microtubules which are critical for its role in bulge stem cell migration and skin wound repair. It may be required for early embryo development and neuron differentiation.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
A synthetic peptide corresponding to residues around Ser9 of Human Phospho-GSK3 beta
抗原种属
Human
研究领域
Notch Pathway
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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关键词

pGSK3 beta (Ser9)pGSK3 beta (S9)GSK3 beta (pSer9)GSK3 beta (pS9)GSK3 beta (phospho-Ser9)GSK3 beta (phospho-S9)

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4个月前
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