购物车
- 全部删除
您的购物车当前为空
Anti-Phospho-GSK3 beta (Ser9) Antibody (7D812)
还可以产品编号 TMAY-01513
Anti-Phospho-GSK3 beta (Ser9) Antibody (7D812) 是一种 Rabbit 抗体，靶向 Phospho-GSK3 beta (Ser9)。Anti-Phospho-GSK3 beta (Ser9) Antibody (7D812) 可用于 WB。
Anti-Phospho-GSK3 beta (Ser9) Antibody (7D812)
Anti-Phospho-GSK3 beta (Ser9) Antibody (7D812)
还可以产品编号 TMAY-01513
Anti-Phospho-GSK3 beta (Ser9) Antibody (7D812) 是一种 Rabbit 抗体，靶向 Phospho-GSK3 beta (Ser9)。Anti-Phospho-GSK3 beta (Ser9) Antibody (7D812) 可用于 WB。
产品信息正在更新中，如果您想购买，请点击大包装&定制按钮.
大包装 & 定制
联系我们获取更多批次信息
资源下载
产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-Phospho-GSK3 beta (Ser9) Antibody (7D812) is a Rabbit antibody targeting Phospho-GSK3 beta (Ser9). Anti-Phospho-GSK3 beta (Ser9) Antibody (7D812) can be used in WB. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 7D812 |
| 交叉反应 | Human; Species predicted to react based on 100% sequence homology: mouse, rat |
| 验证活性 | 1. Western blot analysis of extracts from serum-starved Hela treated with calyculin A (100nM, 30 min), using Phospho-GSK3 beta (Ser9) Antibody, Rabbit MAb at 1:1000, 1:10000, 1:200000 dilution. (Validation Experiment) 2. Western blot analysis of extracts from serum-starved Hela, untreated (-) or treated with Calyculin A (100 nM, 30 min; +), using Phospho-GSK3 beta (Ser9) rabbit monoclonal Antibody at 1:1000 dilution. |
| 应用 | WB |
| 推荐剂量 | WB: 1:1000-1:5000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with a synthetic peptide corresponding to residues around Ser9 of Human Phospho-GSK3 beta. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | GSK3B is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It Contains 1 protein kinase domain, and is expressed in the testis, thymus, prostate, and ovary and weakly expressed in the lung, brain, and kidney. GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in the GSK3B gene have been implicated in modifying the risk of Parkinson's disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer's disease. GSK3B participates in the Wnt signaling pathway. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB, and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. GSK3B also plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. GSK3B phosphorylates MACF1 and this phosphorylation inhibits the binding of MACF1 to microtubules which are critical for its role in bulge stem cell migration and skin wound repair. It may be required for early embryo development and neuron differentiation. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide corresponding to residues around Ser9 of Human Phospho-GSK3 beta |
| 抗原种属 | Human |
| 研究领域 | Notch Pathway |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
SCI 文献
计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
评论列表
预览
Related Tags: buy Anti-Phospho-GSK3 beta (Ser9) Antibody (7D812) | purchase Anti-Phospho-GSK3 beta (Ser9) Antibody (7D812) | Anti-Phospho-GSK3 beta (Ser9) Antibody (7D812) cost | order Anti-Phospho-GSK3 beta (Ser9) Antibody (7D812)
嗨！有任何问题？点我咨询
评论内容