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4-tert-Octylphenol

Name: 4-tert-Octylphenol
Brand: TargetMol
SKU: T64353
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.77%

货号 T64353Cas号 140-66-9

别名 对特辛基苯酚

4-tert-Octylphenol 是一种干扰内分泌的化学物质及雌激素药物，能诱导子代小鼠脑神经元祖细胞的凋亡，并通过减少溴脱氧尿苷（BrdU）、有丝分裂标志物Ki67以及磷酸组蛋白H3（p-Histone-H3）的表达，导致神经元祖细胞的增殖减少。这种物质不仅会干扰小鼠的大脑发育，还会影响其行为。

4-tert-Octylphenol

一键复制产品信息

很棒

纯度: 99.77%

货号 T64353 别名 对特辛基苯酚Cas号 140-66-9

规格	价格	库存	数量
10 g	¥ 99	现货
1 mL x 10 mM (in DMSO)	¥ 99	现货

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COA HNMR HPLC 产品操作手册

产品介绍

4-tert-Octylphenol AI Summary

4-tert-Octylphenol demonstrates a diverse range of bioactivities. It shows the ability to displace [3H]5alpha dihydrotestosterone from human sex hormone binding globulin with a binding affinity of Kd = 2137.96 nM. In Wistar rat studies, at a dosage of 200 mg/kg, the compound achieves a drug level of 80.0 ng/ml in blood. Additionally, 4-tert-Octylphenol exhibits potency in inhibiting ROR gamma transcriptional activity, estrogen receptor alpha signaling, and both agonistic and antagonistic effects on thyroid hormone receptor beta signaling. It delays death inhibition of the malarial parasite and functions as a USP1/UAF1 inhibitor, inducing DNA re-replication in normal breast cells. The compound also activates the NF-kB signaling pathway, PPARalpha signaling pathway, and the pregnane X receptor (PXR) signaling pathway. Furthermore, it inhibits tyrosyl-DNA phosphodiesterase 1, and blocks entry of Lassa Virus, Marburg Virus, and Ebola Virus. It impacts VEGF-stimulated activities, ADSC/ECFC co-culture nuclear area, CD31-stained tube area, and GLP1 secretion, showcasing a breadth of effects across various cellular processes and signaling pathways..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述

4-tert-Octylphenol, an endocrine-disrupting chemical with estrogenic properties, notably induces apoptosis in offspring mouse brain neuronal progenitor cells. This compound decreases levels of bromodeoxyuridine (BrdU), mitotic marker Ki67, and phospho-histone H3 (p-Histone-H3), thereby diminishing the proliferation of neuronal progenitors. Consequently, 4-tert-Octylphenol adversely affects brain development and behavior in mice.

别名

对特辛基苯酚

化学信息

分子量	206.32
分子式	C₁₄H₂₂O
CAS No.	140-66-9
Smiles	CC(C)(C)CC(C)(C)C1=CC=C(O)C=C1

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 45 mg/mL (218.11 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.69 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8468 mL	24.2342 mL	48.4684 mL	242.3420 mL
5 mM	0.9694 mL	4.8468 mL	9.6937 mL	48.4684 mL
10 mM	0.4847 mL	2.4234 mL	4.8468 mL	24.2342 mL
20 mM	0.2423 mL	1.2117 mL	2.4234 mL	12.1171 mL
50 mM	0.0969 mL	0.4847 mL	0.9694 mL	4.8468 mL
100 mM	0.0485 mL	0.2423 mL	0.4847 mL	2.4234 mL