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顶部生物活性储存和溶解信息计算器

Anti-Gclc Antibody (9K428)

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产品编号 TMAC-01634

别名 Glutamate--cysteine ligase catalytic subunit, Glclc, GCS heavy chain, Gclc, Gamma-glutamylcysteine synthetase, Gamma-ECS

Anti-Gclc Antibody (9K428) 是一种 Rabbit 抗体，靶向 Gclc。Anti-Gclc Antibody (9K428) 可用于 FCM,IHC,WB。

Anti-Gclc Antibody (9K428)

Anti-Gclc Antibody (9K428)

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产品编号 TMAC-01634 别名 Glutamate--cysteine ligase catalytic subunit, Glclc, GCS heavy chain, Gclc, Gamma-glutamylcysteine synthetase, Gamma-ECS

Anti-Gclc Antibody (9K428) 是一种 Rabbit 抗体，靶向 Gclc。Anti-Gclc Antibody (9K428) 可用于 FCM,IHC,WB。

规格价格库存数量
50 μL
¥ 1,495
5日内发货
100 μL
¥ 2,495
5日内发货
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产品介绍

生物活性
产品描述
Anti-Gclc Antibody (9K428) is a Rabbit antibody targeting Gclc. Anti-Gclc Antibody (9K428) can be used in FCM,IHC,WB.
别名Glutamate--cysteine ligase catalytic subunit, Glclc, GCS heavy chain, Gclc, Gamma-glutamylcysteine synthetase, Gamma-ECS
Ig Type
IgG
克隆号
9K428
交叉反应
Human,Rat
应用FCMIHCWB
推荐剂量
WB: 1:500-1000; IHC: 1:50-200; FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景The GCLC gene consists of 16 exons and encodes the 636 amino acid protein g-GCSc (g-glutamylcysteine synthetase heavy subunit), also designated g-L-glutamate-L-cysteine ligase catalytic subunit (GLCLC). g-GCSc is expressed in hemocytes, brain, liver and kidney. g-GCSc associates with a regulatory or modifier subunit, g-GCSm (g-glutamylcysteine synthetase light subunit), to form a heterodimer, g-GCS. g-GCS is the first enzyme involved and the rate determining step in glutathione biosynthesis. Oxidants, cadium and methyl mercury upregulate the transcription of g-GCS. H2O2 regulation depends on the Yap1 protein and the presence of glutamate, glutamine and lysine. Cadium regulates transcription through proteins Met-4, Met-31 and Met-32. Cbf1, a DNA binding protein, inhibits transcription of g-GCS. Chemopreventive compounds cause increased levels of g-GCSc in kidney tissues, which may protect against chemically induced carcinogenesis. A His370Leu amino acid change in g-GCSc causes deficiencies in activity which are responsible for hemolytic anemia and low red blood cell glutathione levels.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
P48506
化学信息
分子量Theoretical: 73 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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关键词

GammaECS

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