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Anti-CD3 zeta/CD247 Antibody (5W525)
还可以产品编号 TMAH-00183
别名 TCRZ, T3Z, IMD25, CD3-ζ, CD3-ZETA, CD3Z, CD3Q, CD3H, CD3 ζ/CD247, CD247 molecule
Anti-CD3 zeta/CD247 Antibody (5W525) 是一种抗体，靶向 CD3 zeta/CD247。Anti-CD3 zeta/CD247 Antibody (5W525) 可用于 ELISA, FCM。
Anti-CD3 zeta/CD247 Antibody (5W525)
Anti-CD3 zeta/CD247 Antibody (5W525)
还可以产品编号 TMAH-00183 别名 TCRZ, T3Z, IMD25, CD3-ζ, CD3-ZETA, CD3Z, CD3Q, CD3H, CD3 ζ/CD247, CD247 molecule
Anti-CD3 zeta/CD247 Antibody (5W525) 是一种抗体，靶向 CD3 zeta/CD247。Anti-CD3 zeta/CD247 Antibody (5W525) 可用于 ELISA, FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,315 | 5日内发货 | |
| 100 μL | ¥ 2,180 | 5日内发货 |
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产品介绍
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抗原信息
| 产品描述 | Anti-CD3 zeta/CD247 Antibody (5W525) is an antibody targeting CD3 zeta/CD247. Anti-CD3 zeta/CD247 Antibody (5W525) can be used in ELISA, FCM. |
| 别名 | TCRZ, T3Z, IMD25, CD3-ζ, CD3-ZETA, CD3Z, CD3Q, CD3H, CD3 ζ/CD247, CD247 molecule |
| Ig Type | Rabbit IgG |
| 克隆号 | 5W525 |
| 交叉反应 | Human |
| 验证活性 | Overlay Peak curve showing Jurkat cells surface stained with TMAH-00183 (red line) at 1:50. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1µg/1*10^6 cells) for 45min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4°C.Control antibody (green line) was rabbit IgG (1µg/1*10^6 cells) used under the same conditions. Acquisition of >10,000 events was performed. |
| 应用 | ELISA, FCM |
| 推荐剂量 | FCM:1:50-1:200. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Cell membrane; Single-pass type I membrane protein. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme. Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN). |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human CD247 |
| 抗原种属 | Human |
| 基因ID | 919 |
| Uniprot ID | |
| 研究领域 | Immunology, Stem cells |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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