store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tetrahydrodeoxycorticosterone(Tetrahydro-11-deoxycorticosterone) 是一种有效的 GABAA 受体正变构调节剂 (PAM),具有神经保护活性, 选择性抑制神经类固醇介导的 GABA 诱发电流在 GABAA 受体上的增强,可用于研究神经疾病。
产品描述 | Tetrahydrodeoxycorticosterone(Tetrahydro-11-deoxycorticosterone) is a potent GABAA receptor orthosteric modulator (PAM) with neuroprotective activity that selectively inhibits neurosteroid-mediated enhancement of GABA-induced currents at the GABAA receptor, and can be used in the study of neurological disorders. |
体外活性 | At physiological concentrations, the endogenous neurosteroid Tetrahydrodeoxycorticosterone (THDOC) selectively enhances tonic currents mediated by αβδ receptors[1]. In the hippocampus, the reduction of neuronal excitability is observed with 10 nM Tetrahydrodeoxycorticosterone, achieved by augmenting tonic αβδ receptor currents. Notably, in thalamocortical neurons, although 100 nM Tetrahydrodeoxycorticosterone enhances tonic currents, the same effect is not observed with 10 nM Tetrahydrodeoxycorticosterone[1]. |
体内活性 | Sufficient concentrations of Tetrahydrodeoxycorticosterone (THDOC) in the brain tissue of mice with hepatic encephalopathy (HE), arising from toxic liver injury, can induce sedation in animals of the same species[2]. |
别名 | 21-Hydroxypregnanolone, Tetrahydro-11-deoxycorticosterone |
分子量 | 334.49 |
分子式 | C21H34O3 |
CAS No. | 567-03-3 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL (269.07 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.9896 mL | 14.9481 mL | 29.8963 mL | 74.7406 mL |
5 mM | 0.5979 mL | 2.9896 mL | 5.9793 mL | 14.9481 mL | |
10 mM | 0.299 mL | 1.4948 mL | 2.9896 mL | 7.4741 mL | |
20 mM | 0.1495 mL | 0.7474 mL | 1.4948 mL | 3.737 mL | |
50 mM | 0.0598 mL | 0.299 mL | 0.5979 mL | 1.4948 mL | |
100 mM | 0.0299 mL | 0.1495 mL | 0.299 mL | 0.7474 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Tetrahydrodeoxycorticosterone 567-03-3 Membrane transporter/Ion channel Neuroscience GABA Receptor 21-Hydroxypregnanolone Tetrahydro-11-deoxycorticosterone Inhibitor inhibitor inhibit