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IL-10R beta/IL-10RB Protein, Human, Recombinant (His)

产品编号 TMPY-01236

别名: CRF2-4, D21S66, CDW210B, interleukin 10 receptor, beta, interleukin 10 receptor, β, CRFB4, IL-10R2, D21S58

IL-10R beta/IL-10RB Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25 kDa and the accession number is Q08334.

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IL-10R beta/IL-10RB Protein, Human, Recombinant (His)

规格	价格/CNY		货期	数量
100 μg	￥ 4,460		5日内发货
1 mg	￥ 29,100		5日内发货

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生物活性	Testing in progress
产品描述	IL-10R beta/IL-10RB Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25 kDa and the accession number is Q08334.

种属	Human
表达系统	HEK293 Cells
标签	C-His
蛋白编号	Q08334
别名	CRF2-4, D21S66, CDW210B, interleukin 10 receptor, beta, interleukin 10 receptor, β, CRFB4, IL-10R2, D21S58
蛋白构建	The extracellular domainof Human IL10Rβ (NP_000619.3) (Met 1-Ser 220) was expressed, fused with a polyhistidine tag at the C-terminus.
蛋白纯度	≥ 92 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.
分子量	25 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Interleukin 10 receptor, beta subunit (IL10RB/IL-10RB) also known as Cytokine receptor family 2 member 4, Interleukin-10 receptor subunit 2, and cytokine receptor family II, member 4, is a subunit for the interleukin-10 receptor. IL10RB/IL-10RB belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins is required for IL10-induced signal transduction. Defects in IL10RB/IL-10RB are the cause of inflammatory bowel disease type 25 (IBD25). It is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn's disease and ulcerative colitis phenotypes. Crohn's disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.

参考文献

1. Josephson K, et al. (2001) Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site. Immunity. 15 (1): 35-46. 2. Yoo KH, et al. (2011) Association of IL10, IL10RA, and IL10RB polymorphisms with benign prostate hyperplasia in Korean population. J Korean Med Sci. 26(5): 659-64.

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Keywords

IL-10R beta/IL-10RB Protein, Human, Recombinant (His) CRF2-4 D21S66 CRFB 4 CDW210B interleukin 10 receptor, beta interleukin 10 receptor, β CRFB4 IL-10R2 D21S58 CRFB-4 recombinant recombinant-proteins proteins protein

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