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Anti-IFNAR1 Antibody (9Q189) 是一种 Rabbit 抗体,靶向 IFNAR1。Anti-IFNAR1 Antibody (9Q189) 可用于 ELISA。
Anti-IFNAR1 Antibody (9Q189) 是一种 Rabbit 抗体,靶向 IFNAR1。Anti-IFNAR1 Antibody (9Q189) 可用于 ELISA。
产品描述 | Anti-IFNAR1 Antibody (9Q189) is a Rabbit antibody targeting IFNAR1. Anti-IFNAR1 Antibody (9Q189) can be used in ELISA. |
Ig Type | Monoclonal Rabbit IgG |
克隆号 | 9Q189 |
交叉反应 | Mouse |
应用 | ELISA |
推荐剂量 | ELISA: 1:5000-1:10000 |
抗体种类 | Monoclonal |
宿主来源 | Rabbit |
构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse IFNAR1 (rM IFNAR1; TMPY-01489; NP_034638.2; Met 1-Thr 429). |
纯化方式 | Protein A |
性状 | Liquid |
缓冲液 | 0.2 μm filtered solution in PBS |
研究背景 | Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1, in which Tyr466 is changed to phenylalanine, can act in a dominant-negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors. |
偶联 | Unconjugated |
免疫原 | Recombinant Mouse IFNAR-1 protein (TMPY-01489) |
抗原种属 | Mouse |
储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
运输方式 | Shipping with blue ice. |
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