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Anti-Topoisomerase II beta Polyclonal Antibody

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货号 TMAB-13678

Anti-Topoisomerase II beta Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Topoisomerase II beta。Anti-Topoisomerase II beta Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-Topoisomerase II beta Polyclonal Antibody

Anti-Topoisomerase II beta Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-13678

Anti-Topoisomerase II beta Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Topoisomerase II beta。Anti-Topoisomerase II beta Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

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产品描述
Anti-Topoisomerase II beta Polyclonal Antibody is a Rabbit antibody targeting Topoisomerase II beta. Anti-Topoisomerase II beta Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human,Rat (predicted:Mouse,Dog,Pig,Cow,Horse,Rabbit,Sheep,Chimpanzee)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Nucleus; nucleolus.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants; however, the second variant has not yet been fully described. [provided by RefSeq, Jul 2008]
抗原信息
免疫原
KLH conjugated synthetic peptide: human Topoisomerase II beta
抗原种属
Human
基因名称
TOP2B
基因ID
7155
蛋白名称
DNA topoisomerase 2-beta
Uniprot ID
Q02880
功能
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly ivolved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.
化学信息
分子量Theoretical: 183 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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