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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Phospho-AMPK beta 1 (Ser108) Polyclonal Antibody

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货号 TMAB-10316

Anti-Phospho-AMPK beta 1 (Ser108) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-AMPK beta 1 (Ser108)。Anti-Phospho-AMPK beta 1 (Ser108) Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF,FCM。

Anti-Phospho-AMPK beta 1 (Ser108) Polyclonal Antibody

Anti-Phospho-AMPK beta 1 (Ser108) Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-10316

Anti-Phospho-AMPK beta 1 (Ser108) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-AMPK beta 1 (Ser108)。Anti-Phospho-AMPK beta 1 (Ser108) Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF,FCM。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

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产品描述
Anti-Phospho-AMPK beta 1 (Ser108) Polyclonal Antibody is a Rabbit antibody targeting Phospho-AMPK beta 1 (Ser108). Anti-Phospho-AMPK beta 1 (Ser108) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,FCM.
Ig Type
IgG
反应种属
Mouse,Rat
应用IHC-PIHC-FrIFFCM
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 2μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
组织特异性Highly expressed in kidney, heart, white adipose tissue, lung and spleen.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008].
抗原信息
免疫原
KLH conjugated Synthesised phosphopeptide: rat AMPK beta 1 around the phosphorylation site of Ser108
抗原种属
Rat
基因名称
PRKAB1
基因ID
83803
蛋白名称
5'-AMP-activated protein kinase subunit beta-1
Uniprot ID
P80386
功能
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
化学信息
分子量Theoretical: 30 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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