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Anti-CCL4 Polyclonal Antibody 2

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货号 TMAB-00312

别名 Small-inducible cytokine A4, SIS-gamma, Scya4, Protein H400, Macrophage inflammatory protein 1-beta (MIP-1-beta), Immune activation protein 2 (ACT-2;ACT2), Ccl4, C-C motif chemokine 4

Anti-CCL4 Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 CCL4。Anti-CCL4 Polyclonal Antibody 2 可用于 IF,IHC-Fr,IHC-P。

Anti-CCL4 Polyclonal Antibody 2

Anti-CCL4 Polyclonal Antibody 2

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货号 TMAB-00312 别名 Small-inducible cytokine A4, SIS-gamma, Scya4, Protein H400, Macrophage inflammatory protein 1-beta (MIP-1-beta), Immune activation protein 2 (ACT-2;ACT2), Ccl4, C-C motif chemokine 4

Anti-CCL4 Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 CCL4。Anti-CCL4 Polyclonal Antibody 2 可用于 IF,IHC-Fr,IHC-P。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

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产品描述
Anti-CCL4 Polyclonal Antibody 2 is a Rabbit antibody targeting CCL4. Anti-CCL4 Polyclonal Antibody 2 can be used in IF,IHC-Fr,IHC-P.
别名Small-inducible cytokine A4, SIS-gamma, Scya4, Protein H400, Macrophage inflammatory protein 1-beta (MIP-1-beta), Immune activation protein 2 (ACT-2;ACT2), Ccl4, C-C motif chemokine 4
Ig Type
IgG
反应种属
Human,Mouse,Rat
应用IFIHC-FrIHC-P
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Secreted.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1 mg/mL
研究背景MIP1 alpha and MIP1 beta were originally co-purified from medium conditioned by an LPS-stimulated murine macrophage cell line. Human MIP1 beta refers to the products of several independently cloned cDNAs, including Act2, PAT 744, hH400, G26, HIMAP, HC21, and MAD 5a. The predicted protein products of these cDNAs represent variants that are between 94% - 98% identical and these proteins are all approximately 75% homologous to murine MIP1 beta. MIP1 beta also shares approximately 70% amino acid identity with MIP1 alpha. MIP1 proteins are expressed primarily in T cells, B cells, and monocytes after antigen or mitogen stimulation. The MIP1 proteins have chemoattractant and adhesive effects on lymphocytes, with MIP1 alpha and MIP1 beta preferentially attracting CD8+ and CD4+ T cells, respectively. A signal transducing receptor designated the CC chemokine receptor 1 (CC CKR1) with seven transmembrane domains that binds MIP1 alpha, MIP1 beta, MCP1 and RANTES with varying affinities has been isolated.
抗原信息
免疫原
KLH conjugated synthetic peptide: mouse CCL4
抗原种属
Mouse
基因名称
CCL4
基因ID
20303
蛋白名称
C-C motif chemokine 4
Uniprot ID
P14097
研究领域
HIV-related,Beta Chemokines (CC),Macrophage / Inflamm.,Cytokines and cytokine receptors ELISA kits
功能
Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
化学信息
分子量Theoretical: 7.8 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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关键词

SIS-γSISγSIS-GScya 4MIP-1-βMIP1βMIP-1-betaMIP1betaMIP-1-bMip1bMacrophage inflammatory protein 1-β (MIP-1-β)Macrophage inflammatory protein 1-b (MIP-1-b)Ccl 4ACT-2ACT2

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