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Anti-Phospho-PTEN (Ser380) Antibody (5A114)
还可以产品编号 TMAY-01655
Anti-Phospho-PTEN (Ser380) Antibody (5A114) 是一种 Rabbit 抗体，靶向 Phospho-PTEN (Ser380)。Anti-Phospho-PTEN (Ser380) Antibody (5A114) 可用于 WB。
Anti-Phospho-PTEN (Ser380) Antibody (5A114)
Anti-Phospho-PTEN (Ser380) Antibody (5A114)
还可以产品编号 TMAY-01655
Anti-Phospho-PTEN (Ser380) Antibody (5A114) 是一种 Rabbit 抗体，靶向 Phospho-PTEN (Ser380)。Anti-Phospho-PTEN (Ser380) Antibody (5A114) 可用于 WB。
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偶联与修饰
抗原信息
| 产品描述 | Anti-Phospho-PTEN (Ser380) Antibody (5A114) is a Rabbit antibody targeting Phospho-PTEN (Ser380). Anti-Phospho-PTEN (Ser380) Antibody (5A114) can be used in WB. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 5A114 |
| 交叉反应 | Human; Species predicted to react based on 100% sequence homology: mouse, rat, cynomolgus |
| 验证活性 | Western blot analysis of extracts from Hela, untreated (line A); treated with λ-phosphatase (line B) using Phospho-PTEN (Ser380) rabbit monoclonal Antibody at 1:1000 dilution. (We are unsure as to the identity of these extra bands.) |
| 应用 | WB |
| 推荐剂量 | WB: 1:500-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with a synthetic phosphopeptide corresponding to residues around Ser380 of the Human Phospho-PTEN. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL BSA, 50% glycerol, pH 7.5 |
| 研究背景 | PTEN gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translations start codons results in multiple transcript variants encoding different isoforms.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic phosphopeptide corresponding to residues around Ser380 of the Human Phospho-PTEN |
| 抗原种属 | Human |
| 研究领域 | Phosphatases and Regulators, Tumor Suppressors, Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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