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顶部生物活性储存和溶解信息计算器

Anti-Phospho-PTEN (Ser380) Antibody (5A114)

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Anti-Phospho-PTEN (Ser380) Antibody (5A114)
产品编号 TMAY-01655
别名 TEP1, PTENgama, PTENbeta, PTEN1, PTEN (p-Ser380), PTEN (p-S380), p-PTEN (Ser380), p-PTEN (S380), Phospho-PTEN (S380), MMAC1, MHAM, GLM2, DEC, CWS1, BZS, 10q23del

Anti-Phospho-PTEN (Ser380) Antibody (5A114) 是一种 Rabbit 抗体，靶向 Phospho-PTEN (Ser380)。Anti-Phospho-PTEN (Ser380) Antibody (5A114) 可用于 WB。

Anti-Phospho-PTEN (Ser380) Antibody (5A114)
331

Anti-Phospho-PTEN (Ser380) Antibody (5A114)

Rating icon 还可以
Anti-Phospho-PTEN (Ser380) Antibody (5A114)
产品编号 TMAY-01655 别名 TEP1, PTENgama, PTENbeta, PTEN1, PTEN (p-Ser380), PTEN (p-S380), p-PTEN (Ser380), p-PTEN (S380), Phospho-PTEN (S380), MMAC1, MHAM, GLM2, DEC, CWS1, BZS, 10q23del

Anti-Phospho-PTEN (Ser380) Antibody (5A114) 是一种 Rabbit 抗体，靶向 Phospho-PTEN (Ser380)。Anti-Phospho-PTEN (Ser380) Antibody (5A114) 可用于 WB。

规格价格库存数量
20 μL
¥ 679
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100 μL
¥ 1,979
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-PTEN (Ser380) Antibody (5A114) is a Rabbit antibody targeting Phospho-PTEN (Ser380). Anti-Phospho-PTEN (Ser380) Antibody (5A114) can be used in WB.
别名TEP1, PTENgama, PTENbeta, PTEN1, PTEN (p-Ser380), PTEN (p-S380), p-PTEN (Ser380), p-PTEN (S380), Phospho-PTEN (S380), MMAC1, MHAM, GLM2, DEC, CWS1, BZS, 10q23del
Ig Type
Rabbit IgG
克隆号
5A114
交叉反应
Human;
Species predicted to react based on 100% sequence homology: mouse, rat, cynomolgus
验证活性
Western blot analysis of extracts from Hela, untreated (line A); treated with λ-phosphatase (line B) using Phospho-PTEN (Ser380) rabbit monoclonal Antibody at 1:1000 dilution. (We are unsure as to the identity of these extra bands.)
应用
WB
推荐剂量
WB: 1:500-1:2000
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with a synthetic phosphopeptide corresponding to residues around Ser380 of the Human Phospho-PTEN.
纯化方式Protein A
性状Liquid
缓冲液10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL BSA, 50% glycerol, pH 7.5
研究背景PTEN gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translations start codons results in multiple transcript variants encoding different isoforms.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
A synthetic peptide: residues around Ser380 of the Human Phospho-PTEN
抗原种属
Human
研究领域
Phosphatases and Regulators, Tumor Suppressors, Cancer Drug Targets
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

计算器

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关键词

PTEN (pSer380)PTEN (pS380)PTEN (phospho-Ser380)PTEN (phospho-S380)pPTEN (Ser380)pPTEN (S380)

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4个月前
5.0
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