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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Beta catenin Antibody (4P106)

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货号 TMAB-03105

Anti-Beta catenin Antibody (4P106) 是一种 Rabbit 抗体，靶向 Beta catenin。Anti-Beta catenin Antibody (4P106) 可用于 WB,IHC-P,IF,IHC-Fr。

Anti-Beta catenin Antibody (4P106)

Anti-Beta catenin Antibody (4P106)

一键复制产品信息
Rating icon 还可以
货号 TMAB-03105

Anti-Beta catenin Antibody (4P106) 是一种 Rabbit 抗体，靶向 Beta catenin。Anti-Beta catenin Antibody (4P106) 可用于 WB,IHC-P,IF,IHC-Fr。

规格价格库存数量
25 μL
¥ 785
5日内发货
50 μL
¥ 1,390
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍

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产品描述
Anti-Beta catenin Antibody (4P106) is a Rabbit antibody targeting Beta catenin. Anti-Beta catenin Antibody (4P106) can be used in WB,IHC-P,IF,IHC-Fr.
Ig Type
IgG
克隆号
4P106
反应种属
Human,Mouse,Rat
应用WBIHC-PIFIHC-Fr
推荐剂量
WB: 1:1000-5000; IHC-P: 1:200-800; IF: 1:200-800; IHC-Fr: 1:200-800
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction. Cell membrane. Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Cytoplasmic when it is unstabilized (high level of phosphorylation) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation). Interaction with GLIS2 and MUC1 promotes nuclear translocation. Interaction with EMD inhibits nuclear localization. The majority of beta-catenin is localized to the cell membrane. In interphase, colocalizes with CROCC between CEP250 puncta at the proximal end of centrioles, and this localization is dependent on CROCC and CEP250. In mitosis, when NEK2 activity increases, it localizes to centrosomes at spindle poles independent of CROCC. Co-localizes with CDK5 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells.
组织特异性Expressed in several hair follicle cell types: basal and peripheral matrix cells, and cells of the outer and inner root sheaths. Expressed in colon. Present in cortical neurons (at protein level).
构建方式Recombinant Antibody
纯化方式Affinity Purification
性状Liquid
缓冲液PBS with 100 μg/ml BSA, 0.15% ProClin300 and 50% glycerol.
研究背景Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes.
抗原信息
免疫原
A synthesized peptide: human beta Catenin
抗原种属
Mouse
基因名称
CTNNB1
基因ID
12387
蛋白名称
Catenin beta-1
Uniprot ID
Q02248
功能
Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML.
化学信息
分子量Theoretical: 85 kDa. Actual: 92 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

  • 稀释 计算器
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