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IL-1 beta/IL-1F2 Protein, Human, Recombinant (His)

产品编号 TMPY-01999

别名: IL-1, IL1-β, 白介素, IL1-BETA, 白细胞介素, IL1F2, IL-1B, interleukin 1, beta, IL-1 β, interleukin 1, β, IL-1 beta

IL-1 beta/IL-1F2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 32.3 kDa and the accession number is P01584.

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IL-1 beta/IL-1F2 Protein, Human, Recombinant (His)

规格	价格/CNY		货期	数量
100 μg	￥ 4,930		现货
200 μg	￥ 8,460		5日内发货
500 μg	￥ 17,210		5日内发货

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参考文献

生物活性	1. Measured by its binding ability in a functional ELISA. 2. Immobilized human IL1B at 10 μg/mL (100 μl/well) can bind human IL1R1. The EC50 of human IL1R1 is 0.198 μg/mL.
产品描述	IL-1 beta/IL-1F2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 32.3 kDa and the accession number is P01584.

种属	Human
表达系统	E. coli
标签	N-His
蛋白编号	P01584
别名	IL-1, IL1-β, 白介素, IL1-BETA, 白细胞介素, IL1F2, IL-1B, interleukin 1, beta, IL-1 β, interleukin 1, β, IL-1 beta
蛋白构建	The pro form of Human IL1β (NP_000567.1, with mutation Glu 6 Lys) (Met 1-Ser 269) was fused with a polyhistidine tag at the N-terminus.
蛋白纯度	> 95 % as determined by SDS-PAGE
分子量	32.3 kDa (predicted)

内毒素	Please contact us for more information.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra). In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishment of a successful pregnancy. Proinflammatory interleukin (IL)-1 gene polymorphisms associated with high levels of IL-1beta activity increase the risk for hypochlorhydria and distal gastric carcinoma. IL1B polymorphisms may be involved in susceptibility to SSc. Moreover, the IL2-384-G allele may be a marker for the limited phenotype of systemic sclerosis (SSc).Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

参考文献

1. Kim SH,et al.(2008) Association of -31TC and -511 CT polymorphisms in the interleukin 1 beta (IL1B) promoter in Korean keratoconus patients. Mol Vis. 14:2109-16. 2. Wang ZC,et al.(2002) T helper 1-type immunity to trophoblast antigens in women with a history of recurrent pregnancy loss is associated with polymorphism of the IL1B promoter region. Genes Immun. 3(1): 38-42. 3. Mattuzzi S,et al.(2007) Association of polymorphisms in the IL1B and IL2 genes with susceptibility and severity of systemic sclerosis. J Rheumatol. 34(5): 997-1004.

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Keywords

IL-1 beta/IL-1F2 Protein, Human, Recombinant (His) IL-1 IL1 IL1-β 白介素 IL1-BETA 白细胞介素 IL1F2 IL-1B interleukin 1, beta IL-1 β IL 1 interleukin 1, β IL-1 beta recombinant recombinant-proteins proteins protein

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