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IL-12RB2 Protein, Cynomolgus, Recombinant (mFc)

产品编号 TMPY-06428

IL-12RB2 Protein, Cynomolgus, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 94.93 kDa and the accession number is XP_005543136.1.

IL-12RB2 Protein, Cynomolgus, Recombinant (mFc)

产品编号 TMPY-06428

IL-12RB2 Protein, Cynomolgus, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 94.93 kDa and the accession number is XP_005543136.1.

规格	价格	库存
5 μg	¥ 492	6-8日内发货
10 μg	¥ 785	6-8日内发货
20 μg	¥ 1,320	6-8日内发货
50 μg	¥ 2,620	6-8日内发货
100 μg	¥ 4,430	6-8日内发货
200 μg	¥ 7,760	6-8日内发货
500 μg	¥ 16,300	6-8日内发货
1 mg	¥ 28,800	6-8日内发货

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产品信息

生物活性	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
产品描述	IL-12RB2 Protein, Cynomolgus, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 94.93 kDa and the accession number is XP_005543136.1.
种属	Cynomolgus
表达系统	HEK293 Cells
标签	C-mFc
蛋白编号	XP_005543136.1
别名	interleukin 12 receptor, β2,interleukin 12 receptor, beta 2
蛋白构建	A DNA sequence encoding the Cynomolgus IL12RB2 (XP_005543136.1) (Lys24-Asn623) was expressed with the Fc region of mouse IgG2a at the C-terminus. Predicted N terminal: Lys 24
蛋白纯度	≥ 90 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.
分子量	94.93 kDa (predicted); 111.51 kDa (reducing conditions)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Interleukin-12 receptor subunit beta-2 (IL12RB2), also known as IL-12 receptor subunit beta-2, IL-12R subunit beta-2, IL-12R-beta-2, and IL-12RB2, is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. IL12RB2 belongs to the type I cytokine receptor family. The coexpression of IL12RB2 and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of IL12RB2 is up-regulated by IFN gamma in Th1 cells and plays a role in Th1 cell differentiation. The up-regulation of IL12RB2 is found to be associated with some infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. IL12RB2 promotes the proliferation of T-cells as well as NK cells. IL12RB2 induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.