规格

价格

库存

数量

500 μg

¥ 1,350

现货

生物活性

产品描述

Mu-6S-Palm-β-Glc is a fluorogenic substrate specifically designed for palmitoyl-protein thioesterase (PPT). It is enzymatically cleaved by PPT1 to release the fluorescent 4-methylumbelliferone (MU) moiety, enabling sensitive quantification of enzyme activity. This substrate is a critical tool in the study of infantile neuronal ceroid lipofuscinosis (INCL), a lysosomal storage disorder. It is utilized for both prenatal and postnatal diagnostic assays, as well as in the evaluation of bi-functional IgG-lysosomal enzyme fusion proteins for brain-targeted drug delivery.

体外活性

Mu-6S-Palm-β-Glc 是一种高灵敏度荧光底物，用于快速检测细胞或组织样本中的 PPT1 活性。在 INCL 患者样本中，其荧光信号变化可精确反映 PPT1 活性缺失，是诊断该病及评估酶替代疗效的标准工具。与 β-葡萄糖苷酶联用可进一步提高检测效率 [1][2]。

化学信息

分子量	592.78
分子式	C₃₂H₄₈O₈S
CAS No.	229644-17-1
Smiles	CC=1C=2C(=CC(O[C@@H]3O[C@H](CSC(CCCCCCCCCCCCCCC)=O)[C@@H](O)[C@H](O)[C@H]3O)=CC2)OC(=O)C1

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 24 mg/mL (40.49 mM), Sonication is recommended.

DMF: 15 mg/mL (25.3 mM), Sonication is recommended.

溶液配制表

DMF/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6870 mL	8.4348 mL	16.8697 mL	84.3483 mL
5 mM	0.3374 mL	1.6870 mL	3.3739 mL	16.8697 mL
10 mM	0.1687 mL	0.8435 mL	1.6870 mL	8.4348 mL
20 mM	0.0843 mL	0.4217 mL	0.8435 mL	4.2174 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

Mu-6S-Palm-β-Glc

Mu-6S-Palm-β-Glc

产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换

关键词