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Anti-PIK3CB Antibody (8S549)
还可以产品编号 TMAH-00979
别名 PtdIns-3-kinase subunit p110-beta, PtdIns-3-kinase subunit beta, PIK3C1, PI3-kinase subunit beta, PI3K-beta, PI3Kbeta, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta, p110beta, EC 2.7.1.153
Anti-PIK3CB Antibody (8S549) 是一种抗体，靶向 PIK3CB。Anti-PIK3CB Antibody (8S549) 可用于 ELISA, WB, IP。
Anti-PIK3CB Antibody (8S549)
Anti-PIK3CB Antibody (8S549)
还可以产品编号 TMAH-00979 别名 PtdIns-3-kinase subunit p110-beta, PtdIns-3-kinase subunit beta, PIK3C1, PI3-kinase subunit beta, PI3K-beta, PI3Kbeta, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta, p110beta, EC 2.7.1.153
Anti-PIK3CB Antibody (8S549) 是一种抗体，靶向 PIK3CB。Anti-PIK3CB Antibody (8S549) 可用于 ELISA, WB, IP。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,305 | 5日内发货 | |
| 100 μL | ¥ 2,185 | 5日内发货 |
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抗原信息
| 产品描述 | Anti-PIK3CB Antibody (8S549) is an antibody targeting PIK3CB. Anti-PIK3CB Antibody (8S549) can be used in ELISA, WB, IP. |
| 别名 | PtdIns-3-kinase subunit p110-beta, PtdIns-3-kinase subunit beta, PIK3C1, PI3-kinase subunit beta, PI3K-beta, PI3Kbeta, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta, p110beta, EC 2.7.1.153 |
| Ig Type | Rabbit IgG |
| 克隆号 | 8S549 |
| 交叉反应 | Human |
| 验证活性 | 1. Western Blot -Positive WB detected in: Hela whole cell lysate, K562 whole cell lysate -All lanes: PIK3CB antibody at 1:1500 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 123 kDa -Observed band size: 110 kDa 2. Immunoprecipitating PIK3CB in K562 whole cell lysate -Lane 1: Rabbit control IgG instead of TMAH-00979 in K562 whole cell lysate. For western blotting,a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000) -Lane 2: TMAH-00979(2µg)+ K562 whole cell lysate(500µg) -Lane 3: K562 whole cell lysate (10µg) |
| 应用 | ELISA, WB, IP |
| 推荐剂量 | WB:1:500-1:5000; IP:1:200-1:1000. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Cytoplasm. Nucleus. Note=Interaction with PIK3R2 is required for nuclear localization and export. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol derivatives at position 3 of the inositol ring to produce 3-phosphoinositides. Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human PI3 Kinase p110 beta |
| 抗原种属 | Human |
| 基因ID | 5291 |
| Uniprot ID | |
| 研究领域 | Cell biology, Immunology, Signal transduction |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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