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Anti-Apolipoprotein H/APOH Antibody (5T651)

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Anti-Apolipoprotein H/APOH Antibody (5T651)
产品编号 TMAY-01773
别名 BG, B2GP1, B2G1, apolipoprotein H (β-2-glycoprotein I), apolipoprotein H (beta-2-glycoprotein I)

Anti-Apolipoprotein H/APOH Antibody (5T651) 是一种 Rabbit 抗体,靶向 Apolipoprotein H/APOH。Anti-Apolipoprotein H/APOH Antibody (5T651) 可用于 ELISA,IHC-P。

Anti-Apolipoprotein H/APOH Antibody (5T651)
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Anti-Apolipoprotein H/APOH Antibody (5T651)

Rating icon 还可以
Anti-Apolipoprotein H/APOH Antibody (5T651)
产品编号 TMAY-01773 别名 BG, B2GP1, B2G1, apolipoprotein H (β-2-glycoprotein I), apolipoprotein H (beta-2-glycoprotein I)

Anti-Apolipoprotein H/APOH Antibody (5T651) 是一种 Rabbit 抗体,靶向 Apolipoprotein H/APOH。Anti-Apolipoprotein H/APOH Antibody (5T651) 可用于 ELISA,IHC-P。

规格价格库存数量
20 μL
¥ 780
5日内发货
100 μL
¥ 2,294
5日内发货
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产品介绍

生物活性
产品描述
Anti-Apolipoprotein H/APOH Antibody (5T651) is a Rabbit antibody targeting Apolipoprotein H/APOH. Anti-Apolipoprotein H/APOH Antibody (5T651) can be used in ELISA,IHC-P.
别名BG, B2GP1, B2G1, apolipoprotein H (β-2-glycoprotein I), apolipoprotein H (beta-2-glycoprotein I)
Ig Type
Rabbit IgG
克隆号
5T651
交叉反应
Human
验证活性
Immunochemical staining of human APOH in human liver with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).
应用
ELISA,IHC-P
推荐剂量
ELISA: 1:5000-1:10000; IHC-P: 1:100-1:500
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Human Apolipoprotein H / APOH (rh Apolipoprotein H / APOH; TMPY-01278; NP_000033.2; Met 1-Cys345).
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景Apolipoprotein H (APOH), also known as Beta-2-glycoprotein 1, Activated protein C-binding protein, B2GPI, and B2G1, is a glycoprotein synthesized by liver cells and it is present in the blood associated with plasma lipoproteins. It is an essential cofactor for the binding of certain antiphospholipid antibodies (APA) to anionic phospholipid. APOH binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. APOH may prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells. APOH appears to completely inhibit serotonin release by the platelets and prevents subsequent waves of the ADP-induced aggregation. The activity of APOH appears to involve the binding of agglutenating, negatively charged compounds, and inhibits agglutenation by the contact activation of the intrinsic blood coagulation pathway. APOH causes a reduction of the prothrombinase binding sites on platelets and reduces the activation caused by collagen when thrombin is present at physiological serum concentrations of APOH suggesting a regulatory role of APOH in coagulation. APOH plasma concentrations are strongly associated to metabolic syndrome alterations and vascular disease in type 2 diabetic and could be considered as a clinical marker of cardiovascular risk. APOH is found on several classes of lipoproteins, and is involved in the activation of lipoprotein lipase in lipid metabolism. This single-chain glycoprotein also has been implicated in several physiologic pathways including coagulation and the production of hypertension, which are related to the pathogenesis of primary cerebral hemorrhage (PICH).
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Human APOH protein (TMPY-01278)
抗原种属
Human
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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4个月前
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