Sulfapyridine

Name: Sulfapyridine
Brand: TargetMol
SKU: T0767
Price: 333 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.84%

货号 T0767Cas号 144-83-2

别名 磺胺吡啶, Sulfidine, Sulfidin, 2-Sulfapyridine

Sulfapyridine (2-Sulfapyridine) 是一种磺酰胺类抗生素，是 Sulfasalazine 的代谢产物。它抑制重组 P. carinii 二氢蝶呤合成酶，IC50为 0.18 μM。它具有抗菌，抗炎和抗风湿作用。

Sulfapyridine

一键复制产品信息

很棒

纯度: 99.84%

货号 T0767 别名 磺胺吡啶, Sulfidine, Sulfidin, 2-SulfapyridineCas号 144-83-2

规格	价格	库存
500 mg	¥ 333	现货
1 g	¥ 418	现货
5 g	¥ 671	现货
1 mL x 10 mM (in DMSO)	¥ 460	现货

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纯度: 99.84%

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COA LCMS HPLC HNMR 产品操作手册

产品介绍

Sulfapyridine AI Summary

Sulfapyridine is characterized by a measured pKa of 8.56 and demonstrates notable bioactivity across multiple assays. It inhibits Escherichia coli (K12J53) Dihydropteroate synthase with an EII50 of 4.2 and inhibits E. coli growth in vitro with a GII50 of 1500.0. In guinea pigs, at a concentration of 60 µmol, it induced significant cecal ulceration and weight loss, with a quantitative histological score of 3.11. Pharmacokinetic studies in rats reveal a half-life (T1/2) of 1.47 hours, total clearance (ClT) of 1.79 ml min-1, and an apparent volume of distribution (Vc) of 229.0 ml. It has low permeability through human skin with a LogD value of 0.03, and it binds to protein in rat serum with a K ass of 4592.0 l M-1. Sulfapyridine shows minimal inhibition of PAD4 and HDAC6, but inhibits the xc--cystine-glutamate antiporter-mediated cystine uptake in human U87 cells with an IC50 > 1,000,000 nM. It exhibits antiviral potential against SARS-CoV-2, albeit with low potency, and demonstrates antituberculosis activity against Mycobacterium paratuberculosis. Noticeable liver toxicity and moderate antiviral activity are also observed, with a particular inhibition on the SARS-CoV-2 3CL-Pro protease and VP protein function in VERO-6 cells. Furthermore, it inhibits various molecular targets, including protein tyrosine kinase (PTK) and several other enzymes, with varying potency across different assays. Finally, it exhibits low intrinsic clearance in human liver microsomes and shows pharmacokinetic variability in genetically modified rat models, indicating interactions with specific transporters or metabolic pathways..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Sulfapyridine (2-Sulfapyridine) is a short-acting sulfonamide antibiotic and by-product of the non-steroidal anti-inflammatory drug sulfasalazine.
别名	磺胺吡啶, Sulfidine, Sulfidin, 2-Sulfapyridine

化学信息

分子量	249.29
分子式	C₁₁H₁₁N₃O₂S
CAS No.	144-83-2
Smiles	NC1=CC=C(C=C1)S(=O)(=O)NC1=NC=CC=C1
密度	1.432g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 25 mg/mL (100.28 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (10.03 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0114 mL	20.0570 mL	40.1139 mL	200.5696 mL
5 mM	0.8023 mL	4.0114 mL	8.0228 mL	40.1139 mL
10 mM	0.4011 mL	2.0057 mL	4.0114 mL	20.0570 mL
20 mM	0.2006 mL	1.0028 mL	2.0057 mL	10.0285 mL
50 mM	0.0802 mL	0.4011 mL	0.8023 mL	4.0114 mL
100 mM	0.0401 mL	0.2006 mL	0.4011 mL	2.0057 mL