Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Phosphoribosyl pyrophosphate (PRPP) pentasodium is a vital metabolite essential for the biosynthesis of purine and pyrimidine nucleotides, as well as the amino acids histidine and tryptophan. It also acts as a precursor for the important cofactors NAD and NADP.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 720 | 5日内发货 |
产品描述 | Phosphoribosyl pyrophosphate (PRPP) pentasodium is a vital metabolite essential for the biosynthesis of purine and pyrimidine nucleotides, as well as the amino acids histidine and tryptophan. It also acts as a precursor for the important cofactors NAD and NADP. |
体外活性 | Phosphoribosyl diphosphate (PRPP) pentasodium is an important intermediate in cellular metabolism. PRPP is synthesized by PRPP synthase, as follows: ribose 5-phosphate + ATP → PRPP + AMP. PRPP is ubiquitously found in living organisms and is used in substitution reactions with the formation of glycosidic bonds. PRPP is utilized in the biosynthesis of purine and pyrimidine nucleotides, the amino acids histidine and tryptophan, the cofactors NAD and tetrahydromethanopterin, arabinosyl monophosphodecaprenol, and certain aminoglycoside antibiotics[1]. Phosphoribosyl diphosphate (5-Phosphoribosyl-l-pyrophosphate) pentasodium, a substrate shared by adenine phosphoribosyltransferase and hypoxanthine-guanine phosphoribosyltransferase, accumulates in human erythrocytes lacking hypoxanthine-guanine phosphoribosyltransferase. 5-Phosphoribosyl-l-pyrophosphate added to purified adenine phosphoribosyltransferase stabilizes it against heat inactivation[2]. |
别名 | PRPPpentasodium, 磷酸核糖焦磷酸 |
分子量 | 505.015 |
分子式 | C5H13Na5O14P3 |
CAS No. | 108321-05-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Phosphoribosyl pyrophosphate pentasodium 108321-05-7 Phosphoribosyl Pyrophosphate PRPPpentasodium 磷酸核糖焦磷酸 Inhibitor inhibitor inhibit