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Anti-Phospho-p70 S6 Kinase 1 (Thr389) Antibody (4K165)
还可以产品编号 TMAY-01508
Anti-Phospho-p70 S6 Kinase 1 (Thr389) Antibody (4K165) 是一种 Rabbit 抗体，靶向 Phospho-p70 S6 Kinase 1 (Thr389)。Anti-Phospho-p70 S6 Kinase 1 (Thr389) Antibody (4K165) 可用于 WB。
Anti-Phospho-p70 S6 Kinase 1 (Thr389) Antibody (4K165)
Anti-Phospho-p70 S6 Kinase 1 (Thr389) Antibody (4K165)
还可以产品编号 TMAY-01508
Anti-Phospho-p70 S6 Kinase 1 (Thr389) Antibody (4K165) 是一种 Rabbit 抗体，靶向 Phospho-p70 S6 Kinase 1 (Thr389)。Anti-Phospho-p70 S6 Kinase 1 (Thr389) Antibody (4K165) 可用于 WB。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-Phospho-p70 S6 Kinase 1 (Thr389) Antibody (4K165) is a Rabbit antibody targeting Phospho-p70 S6 Kinase 1 (Thr389). Anti-Phospho-p70 S6 Kinase 1 (Thr389) Antibody (4K165) can be used in WB. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 4K165 |
| 交叉反应 | Human; Species predicted to react based on 100% sequence homology: Mouse, rat |
| 验证活性 | 1. Western blot analysis of extracts from serum-starved MCF7, untreated (line A); treated with IGF-1 (100 ng/mL, 30 min; +) (line B); treated with IGF-1 and λ-phosphatase (line C) using Phospho-S6K1 (Thr389) rabbit monoclonal Antibody at 1:5000 dilution(upper), or Anti-RPS6KB1 rabbit polyclonal antibody (lower) at 1:5000 dilution. 2. Western blot analysis of extracts from serum-starved MCF7, untreated (line A); treated with IGF-1 (100 ng/mL, 30 min), without peptide (line B) or antigen-specific phosphopeptide (line C) or antigen-specific peptide (line D) using Phospho-S6K1 (Thr389) rabbit monoclonal Antibody at 1:5000 dilution. (Validation Experiment) 3. Western blot analysis of extracts from serum-starved MCF7, treated with IGF-1 (100 ng/mL, 30 min), using Phospho-S6K1 (Thr389) rabbit monoclonal Antibody (Sino) and other brands’ antibodies (company C, company P) at dilution of 1:1000, 1:10000 and 1:200000. (Validation Experiment) |
| 应用 | WB |
| 推荐剂量 | WB: 1:1000-1:200000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | The antibody is produced by immunizing rabbits with a synthetic phosphopeptide corresponding to residues around Thr389 of human p70 S6 kinase 1. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | PS6K, also known as RPS6KB1, is a serine/threonine-protein kinase. It belongs to the RSK (ribosomal s6 kinase) family. Members of this family function in signal transduction. PS6K is an isoform of p70 ribosomal S6 kinase (S6K). S6K can be activated by mitogenic stimuli such as growth factors, insulin and cytokines. It phosphorylates the ribosomal protein S6. PS6K also phosphorylates other proteins such as elF4B, eEF2K and SKAR. It is a crucial effector of mTOR(rapamycin) signaling. PS6K is dissociated from the EIF3 complex and activated upon mitogenic stimulation, phosphorylation by the mammalian target of mTOR complex 1 (mTORC1). Its active form then phosphorylates and activates several substrates in the preinitiation complex, including the EIF2B complex and the cap-binding complex component EIF4B. PS6K also functions in cell proliferation, cell growth and cell cycle progression. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic phosphopeptide corresponding to residues around Thr389 of human p70 S6 kinase 1. |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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