Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Protriptyline 是有效的抗抑郁剂,抑制AChE 活性(IC50 =.06 mM),并可抑制 Aβ 自组装。Protriptyline 具有用于抑郁症和阿尔茨海默病的研究潜力。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 6-8周 | ||
50 mg | ¥ 13,800 | 6-8周 | ||
100 mg | ¥ 17,500 | 6-8周 |
产品描述 | Protriptyline is a potent antidepressant agent that inhibits AChE activity with an IC 50 value of 0.06 mM as well as inhibits Aβ Self-Assembly. Protriptyline has the potential to be used for depression and Alzheimer's disease [1] [2] [3]. |
体外活性 | Protriptyline (0-70 μM; 24 hours; PC3 cells) leads to cytotoxicity in PC3 cells [2]. Cell Cytotoxicity Assay [2] Cell Line: PC3 cells Concentration: 50, 60 and 70 μM Incubation Time: 24 hours Result: Concentration-dependently decreased cell viability. |
体内活性 | Protriptyline (10 mg/kg; i.p.; for 21 days; rat model of AD) ameliorates spatial learning and retention memory in STZ treated rats [3]. Animal Model: Rat model of AD [3] Dosage: 10 mg/kg Administration: Intraperitoneal injection; for 21 days. Result: PRT treatment significantly reduced pTau, Aβ42 and BACE-1 levels, neurodegeneration, oxidative stress and glial activation which also significantly improved p-ERK/ERK ratio and enhanced BDNF and CREB levels by reducing NFκB and GFAP expression in STZ treated rats. |
分子量 | 263.38 |
分子式 | C19H21N |
CAS No. | 438-60-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Protriptyline 438-60-8 Inhibitor inhibitor inhibit